Evidence map›Paper›PMID 31315255›Full record

ArticleMolecules (Basel, Switzerland)2019

Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-β

Shuang Liang, Zijian Wang, Jiaqi Yuan, Jing Zhang, Xueling Dai, Fei Qin, Jiayu Zhang, Yaxuan Sun

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Frontiers in cardiovascular medicine · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuang LiangCollege of Biochemical Engineering, Beijing Union University, Beijing 100191, China.
Zijian WangBeijing University of Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing 100191, China.
Jiaqi YuanCollege of Biochemical Engineering, Beijing Union University, Beijing 100191, China.
Jing ZhangCollege of Biochemical Engineering, Beijing Union University, Beijing 100191, China.
Xueling DaiBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Fei QinBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Jiayu ZhangSchool of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Yaxuan SunBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. sunxx@buu.edu.cn.

Funding

Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University LDSP201804Beijing Municipal Outstanding Talent Training Funding 2015000020124G049Premium Funding Project for Academic Human Resources Development in Beijing Union University BPHR2018DZ03
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that damages health and welfare of the elderly, and there has been no effective therapy for AD until now. It has been proved that tanshinone IIA (tan IIA) could alleviate pathological symptoms of AD via improving non-amyloidogenic cleavage of amyloid precursor protein, decreasing the accumulations of p-tau and amyloid-β

Indexed as

AbietanesAdministration, OralAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCA1 Region, HippocampalChromatography, High Pressure LiquidDisease Models, AnimalMaleMass SpectrometryMetabolomicsPeptide FragmentsRatsRats, Sprague-DawleyAbietanesAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentstanshinoneAlzheimer’s diseasehippocampusmetabolic pathwayMorris water maze testpassive avoidance testrat modelTanshinone IIAUHPLC-Q-Exactive Qrbitrap mass spectrometry

Identifiers

PMID31315255
PMCPMC6680413

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.