ArticleInternational journal of geriatric psychiatry2019
Cognitive and functional progression of dementia in two longitudinal studies.
Article in International journal of geriatric psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Latent classes and progression of Mini-Mental State Examination scores in young-onset dementia: Data from the Swedish Dementia Register.Journal of Alzheimer's disease : JAD · 2025Article
- Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework.EBioMedicine · 2025Review
- Effect of fluid intake on cognitive function in older individuals: A prospective study.PloS one · 2025Article
- Cognitive Trajectories in Older Adults Diagnosed With Hematologic Malignant Neoplasms.JAMA network open · 2024Article
- When prion disease Isn't suspected: prion disease as the cause of terminal decline in chronic mixed dementia.Neurocase · 2023Article
- Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.NeuroImage. Clinical · 2020Article
- Cognitive and functional progression of dementia in two longitudinal studies.International journal of geriatric psychiatry · 2019Article
- Meaningful to whom? Minimal clinically important differences and the priorities of individuals living with dementia for everyday function.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
10 authors.
Funding
Abstract
objectivesPrevious studies have identified several subgroups (ie, latent trajectories) with distinct disease progression among people with dementia. However, the methods and results were not always consistent. This study aims to perform a coordinated analysis of latent trajectories of cognitive and functional progression in dementia across two datasets.
methodsIncluded and analyzed using the same statistical approach were 1628 participants with dementia from the US National Alzheimer's Coordinating Center (NACC) and 331 participants with dementia from the Dutch Clinical Course of Cognition and Comorbidity study (4C-Study). Trajectories of cognition and instrumental activities of daily living (IADL) were modeled jointly in a parallel-process growth mixture model.
resultsCognition and IADL tended to decline in unison across the two samples. Slow decline in both domains was observed in 26% of the US sample and 74% of the Dutch sample. Rapid decline in cognition and IADL was observed in 7% of the US sample and 26% of the Dutch sample. The majority (67%) of the US sample showed moderate cognitive decline and rapid IADL decline.
conclusionsTrajectories of slow and rapid dementia progression were identified in both samples. Despite using the same statistical methods, the number of latent trajectories was not replicated and the relative class sizes differed considerably across datasets. These results call for careful consideration when comparing progression estimates in the literature. In addition, the observed discrepancy between cognitive and functional decline stresses the need to monitor dementia progression across multiple domains.
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