Evidence map›Paper›PMID 31323376›Full record

ArticleDrug and alcohol dependence2019

CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms.

Cindy L Ehlers, Evelyn Phillips, Corinne Kim, Derek N Wills, Katherine J Karriker-Jaffe, David A Gilder

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cindy L EhlersNeurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cindye@scripps.edu.
Evelyn PhillipsNeurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Corinne KimNeurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Derek N WillsNeurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Katherine J Karriker-JaffeAlcohol Research Group, Public Health Institute, Emeryville, CA, 94608, USA.
David A GilderNeurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Research Institute · USPublic Health Institute · US

Funding

Individual and community influences on alcohol use disorders and other mental health behaviors in Mexican AmericansR01AA026248 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI EHLERS, CINDY L · 2018 to 2022
$3.5M
NIAAA NIH HHS R01 AA026248
6 · The paper itself

Abstract

backgroundElectrophysiological variables may represent sensitive biomarkers of vulnerability to or endophenotypes for alcohol use disorders (AUD).

methodsYoung adults (age 18-30 yrs, n = 580) of Mexican American heritage were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism and event-related oscillations (EROs) generated in response to a task that used pictures of objects, food, and alcohol-related and non-alcohol-related drinks as stimuli.

resultsDecreases in energy in the alpha and beta frequencies and higher phase synchrony within cortical brain areas were seen in response to the alcohol-related as compared to the non-alcohol-related stimuli. Differences in ERO energy and synchrony responses to alcohol-related stimuli were also found as a function of age, sex, AUD status and comorbidity. Age-related decreases in energy and increases in synchrony were found. Females had significantly higher energy and lower synchrony values than males. Participants with AUD had higher synchrony values specifically in the beta frequencies, whereas those with a lifetime diagnosis of conduct disorder and/or antisocial personality disorder had lower alpha power and synchrony, and those with any affective disorder had lower ERO energy in the beta frequencies. Those with substance-associated affective "dark-side" symptoms had slower reaction times to the task, lower energy in the beta frequencies, lower local synchrony in the theta frequencies, and higher long-range synchrony in the delta and beta frequencies.

conclusionsThese findings suggest that EROs recorded to alcohol-related stimuli may be biomarkers of comorbid risk factors, symptoms and disorders associated with AUD that also can differentiate those with "dark-side symptoms".

Indexed as

Evoked PotentialsTask Performance and AnalysisAdolescentAdultAffective SymptomsAge FactorsAlcoholismAlpha RhythmAntisocial Personality DisorderBeta RhythmBrainComorbidityConduct DisorderFemaleHumansMaleAlcohol-related stimuliComorbidityEvent-related oscillationsMexican American

Identifiers

PMID31323376
PMCPMC6685752
OpenAlexW2955172425

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.