Evidence map›Paper›PMID 31324031›Full record

ReviewCancers2019

Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma.

Susanna Leskela, Belen Pérez-Mies, Juan Manuel Rosa-Rosa, Eva Cristobal, Michele Biscuola, María L Palacios-Berraquero, SuFey Ong, Xavier Matias-Guiu Guia, José Palacios

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 81 citations in OpenAlex.

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  12. Exosomes in Cancer: Diagnostic and Therapeutic Applications.Clinical Medicine Insights. Oncology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Susanna LeskelaDepartment of Pathology, Institute Ramón y Cajal for Health Research, 28034 Madrid, Spain. susanna.leskela@gmail.com.ORCID 0000-0002-9279-8843
Belen Pérez-MiesCIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Juan Manuel Rosa-RosaDepartment of Pathology, Institute Ramón y Cajal for Health Research, 28034 Madrid, Spain.ORCID 0000-0003-0806-6453
Eva CristobalDepartment of Pathology, Institute Ramón y Cajal for Health Research, 28034 Madrid, Spain.
Michele BiscuolaCIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
María L Palacios-BerraqueroDepartment of Hematology and Hemotherapy, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
SuFey OngNanoString Technologies, Inc, Seattle, WA 98109, USA.
Xavier Matias-Guiu GuiaCIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
José PalaciosDepartment of Pathology, Institute Ramón y Cajal for Health Research, 28034 Madrid, Spain. jose.palacios@salud.madrid.org.ORCID 0000-0002-6730-5066
Instituto Cajal · ESInstituto de Salud Carlos III · ESClinica Universidad de Navarra · ESNanostring Technologies (United States) · USUniversidad de Alcalá · ESUniversitat de Lleida · ES

Funding

Fundación Científica Asociación Española Contra el Cáncer AIO-aecc 2016Fundación Científica Asociación Española Contra el Cáncer Grupos Coordinados Traslacionales aecc 2018Instituto de Salud Carlos III CB16/12/00231Instituto de Salud Carlos III CB16/12/00316Instituto de Salud Carlos III CB16/12/00361Instituto de Salud Carlos III PI16/00887Instituto de Salud Carlos III PIE15/00050
6 · The paper itself

Abstract

Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, intratumor heterogeneity in ECS is due to an admixture of epithelial (carcinoma) and mesenchymal (sarcoma) components that can include heterologous tissues, such as skeletal muscle, cartilage, or bone. Most ECSs belong to the copy-number high serous-like molecular subtype of endometrial carcinoma, characterized by the

Indexed as

clonalityendometrial carcinomaepithelial-to-mesenchymal transitiongene expressionmetaplastic carcinomamiRNA expressionmutationPI3K/AKT pathwayTP53uterine carcinosarcoma

Identifiers

PMID31324031
PMCPMC6678708
OpenAlexW2959651197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.