Evidence map›Paper›PMID 31327761›Full record

ArticleAging2019

miR-548d-3p inhibits osteosarcoma by downregulating

Jianhua Chen, Chongnan Yan, Honghao Yu, Shihan Zhen, Quan Yuan

Abstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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  11. Article
  12. miR-548d-3p Alters Parasite Growth and Inflammation inFrontiers in cellular and infection microbiology · 2021
    Article
  13. Article
  14. Article
  15. MiR-548d-3p Promotes Gastric Cancer by Targeting RSK4.Cancer management and research · 2020
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianhua ChenDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Chongnan YanDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Honghao YuDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Shihan ZhenDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Quan YuanDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines.

Indexed as

Gene Expression Regulation, NeoplasticAdolescentAdultAnimalsBone NeoplasmsCell Line, TumorChildDown-RegulationFemaleHumansMaleMiceMicroRNAsOsteosarcomaProto-Oncogene Proteins p21(ras)Young AdultKRAS protein, humanMicroRNAsMIRN548 microRNA, humanProto-Oncogene Proteins p21(ras)growthKRASmigrationmiR-548d-3posteosarcoma

Identifiers

PMID31327761
PMCPMC6682526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.