Evidence map›Paper›PMID 31332384›Full record

ArticleNature microbiology2019

Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance.

Sophia R Levan, Kelsey A Stamnes, Din L Lin, Ariane R Panzer, Elle Fukui, Kathryn McCauley, Kei E Fujimura, Michelle McKean, Dennis R Ownby, Edward M Zoratti and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 159 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 1 synthesis or guideline pooled it, 228 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Review
  6. MaternalBiomedicines · 2026
    Article
  7. Article
  8. Article
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  11. Live and heat-treatediScience · 2026
    Article
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  13. Review
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  18. Article
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sophia R LevanDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kelsey A StamnesDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Din L LinDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ariane R PanzerDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Elle FukuiDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kathryn McCauleyDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kei E FujimuraDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Michelle McKeanDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Dennis R OwnbySection of Allergy-Immunology, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0003-0944-6466
Edward M ZorattiDepartment of Internal Medicine, Division of Allergy and Immunology, Henry Ford Health System, Detroit, MI, USA.
Homer A BousheyDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Michael D CabanaDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9376-2167
Christine C JohnsonDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. susan.lynch@ucsf.edu.ORCID http://orcid.org/0000-0001-5695-7336
University of California, San Francisco · USHenry Ford Health System · USAugusta University · US

Funding

The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI LUKACS, NICHOLAS W · 2012 to 2024
$25.7M
NIAID NIH HHS P01 AI089473
6 · The paper itself

Abstract

Neonates at risk of childhood atopy and asthma exhibit perturbation of the gut microbiome, metabolic dysfunction and increased concentrations of 12,13-diHOME in their faeces. However, the mechanism, source and contribution of this lipid to allergic inflammation remain unknown. Here, we show that intra-abdominal treatment of mice with 12,13-diHOME increased pulmonary inflammation and decreased the number of regulatory T (T

Indexed as

AnimalsAsthmaBacteriaBacterial Physiological PhenomenaBacterial ProteinsDisease Models, AnimalEpoxide HydrolasesFecesFemaleGastrointestinal MicrobiomeHumansImmune ToleranceInfant, NewbornLinoleic AcidsMaleMiceBacterial ProteinsEpoxide HydrolasesLinoleic Acids

Identifiers

PMID31332384
PMCPMC6830510
OpenAlexW2963614304

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.