ArticleMedicine2019
Effects of long-term glycemic variability on incident cardiovascular disease and mortality in subjects without diabetes: A nationwide population-based study.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- A single arm trial using passive simulated jogging for blunting acute hyperglycemia.Scientific reports · 2021Trial
- Impact of Hospitalist-Led Care on Glycemic Control Among Hospitalized Adults with Diabetes in Korea.Journal of clinical medicine · 2026Article
- Linking glucose swings and mental health to cardiovascular outcomes and mortality in general practice.Scientific reports · 2025Article
- What is Glycaemic Variability and which Pharmacological Treatment Options are Effective? A Narrative Review.TouchREVIEWS in endocrinology · 2023Review
- Effects of metabolic parameters' variability on cardiovascular outcomes in diabetic patients.Cardiovascular diabetology · 2023Article
- Prediabetes, Non-Dipping Profile and Hypertension-A Recipe for Increased Arterial Stiffness.Biomedicines · 2023Article
- Effects of reducing free sugars on 24-hour glucose profiles and glycemic variability in subjects without diabetes.Frontiers in nutrition · 2023Article
- Glucose variability: A physiological correlate of eating disorder behaviors among individuals with binge-spectrum eating disorders.The International journal of eating disorders · 2022 · on this mapArticle
- Association between visit-to-visit fasting glycemic variability and depression: a retrospective cohort study in a representative Korean population without diabetes.Scientific reports · 2022Article
- Associations Between Device-Measured Physical Activity and Glycemic Control and Variability Indices Under Free-Living Conditions.Diabetes technology & therapeutics · 2022Article
- Implications of fasting plasma glucose variability on the risk of incident peripheral artery disease in a population without diabetes: a nationwide population-based cohort study.Cardiovascular diabetology · 2022Article
- Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes.Diabetes & metabolism journal · 2022Review
- Body shape and risk of glaucoma: A Mendelian randomization.Frontiers in medicine · 2022Article
- Significance of day-to-day glucose variability in patients after acute coronary syndrome.BMC cardiovascular disorders · 2021Article
- Acute Glucose Shift Induces the Activation of the NLRP3 Inflammasome in THP-1 Cells.International journal of molecular sciences · 2021Article
- Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk.Journal of clinical medicine · 2021Review
- Associations of Physical Activity Level and Variability With 6-Month Weight Change Among 26,935 Users of Connected Devices: Observational Real-Life Study.JMIR mHealth and uHealth · 2021Observational
- Identifying Glycemic Variability in Diabetes Patient Cohorts and Evaluating Disease Outcomes.Journal of clinical medicine · 2021Article
- New Insights into the Role of Visit-to-Visit Glycemic Variability and Blood Pressure Variability in Cardiovascular Disease Risk.Current cardiology reports · 2021Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased glycemic variability (GV) is an independent risk factor for cardiovascular complications in patients with diabetes. We evaluated the risk of future development of cardiovascular disease (CVD) and death according to GV in a general population without diabetes.We used the National Health Insurance Service, providing a population-based, nationwide database of Koreans. We included individuals without diabetes who underwent glucose measurement at least 3 times during 2002 to 2006. GV was calculated as standard deviation (SD) of fasting plasma glucose (FPG) levels. We observed development of CVD or all-cause death from 2007 to 2015, and also evaluated the mortality within 1 year after CVD.Among 3,211,319 people, we found 23,374 incident cases of myocardial infarction (MI), 27,705 cases of stroke, and 63,275 deaths during 8.3 years of follow-up. After multivariate adjustment, GV was found to be a significant predictor of MI, stroke and all-cause death for their highest quartile, with corresponding hazard ratios (HR) of 1.08 (95% confidence interval, CI 1.04-1.11), 1.09 (95% CI 1.06-1.13), and 1.12 (95% CI 1.10-1.15), respectively. The risk of death increased more in those who had both impaired fasting glucose and the highest quartile of GV (HR 1.24 [95% CI 1.21-1.28]). Moreover, early death rate after 1 year of CVD was higher in the highest quartile of GV compared to the lowest quartile (HR 1.21 [95% CI 1.03-1.41]).Long-term FPG variation was independently associated with CVD and mortality in a general population without diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.