ArticleEJNMMI physics2019
Imaging cardiac sympathetic innervation with MIBG: linear conversion of the heart-to-mediastinum ratio between different collimators.
Article in EJNMMI physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Neuroimaging biomarkers in the biological definition of Parkinson's disease and dementia with Lewy bodies - EANM position on current state, unmet needs and future perspectives.European journal of nuclear medicine and molecular imaging · 2024Article
- Application ofJapanese journal of radiology · 2023Article
- Cardiac sympathetic denervation could be associated with dysphagia in Parkinson's disease.Frontiers in neurology · 2022Article
- Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy.NPJ Parkinson's disease · 2020Article
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7 authors.
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Abstract
backgroundThe heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we investigated whether an empirical linear conversion of H/M ratios between camera systems with low-energy (LE) and medium-energy (ME) collimator is possible.
methodsWe included 18 patients with parkinsonism who were referred to one of the two participating molecular imaging facilities for the evaluation of cardiac sympathetic innervation by MIBG scintigraphy. Two consecutive planar image datasets were acquired with LE and ME collimators at 4 h after MIBG administration. Linear regression analyses were performed to describe the association between the H/M ratios gained with both collimator settings, and the accuracy of a linear transfer of the H/M ratio between collimators and across centers was assessed using a leave-one-out procedure.
resultsH/M ratios acquired with LE and ME collimators showed a strong linear relationship both within each imaging facility (R
conclusionsThe present study demonstrates that a simple linear conversion of H/M ratios acquired with different collimators is possible with high accuracy. This should greatly facilitate the exchange of normative data between settings and pooling of data from different institutions.
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