ReviewMolecular psychiatry2019
Genomics and psychological resilience: a research agenda.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Child maltreatment and resilience in adulthood: a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Efficacy of a transdiagnostic, prevention-focused program for at-risk young adults: a waitlist-controlled trial.Psychological medicine · 2023Trial
- Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores.Schizophrenia bulletin · 2026Article
- Polygenic Resilience Scores are Associated With Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and Cognition.Schizophrenia bulletin · 2026Article
- Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.Schizophrenia bulletin · 2026Article
- Genetics of educational resilience after adverse childhood experiences.EBioMedicine · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Dominant depressive temperament and psychological resilience in obsessive-compulsive disorder.BMC psychiatry · 2025Article
- The relationship between adverse childhood experiences and resilience among college students in Saudi arabia: a cross-sectional study.Scientific reports · 2025Article
- Positive childhood experiences in obesity and hypertension among young adults: Associations across adverse childhood experiences levels.American journal of preventive cardiology · 2025Article
- Effects of Adverse Childhood Experiences on Depression Among Chinese College Students: A Mediated Moderation Model of "Shift-and-Persist" Strategy and Perceived Everyday Discrimination.Behavioral sciences (Basel, Switzerland) · 2025Article
- The Psychiatric Genomics Consortium: discoveries and directions.The lancet. Psychiatry · 2025Review
- Stress Resilience and Risk of Psychiatric Disorders After Childhood Bereavement.JAMA network open · 2025Article
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- How can we build structural resilience? Integration of social-ecological and minority stress models.The American psychologist · 2024Article
- Study on psychological resilience and associated influencing factors in lung cancer patients with bone metastases.World journal of psychiatry · 2024Article
- The relationship between corona disease anxiety and sleep disturbances and suicidal ideation in medical staff: The mediating role of resiliency and cognitive flexibility: A cross-sectional study.Health science reports · 2024Article
- Coping and emotion regulation: A conceptual and measurement scoping review.Canadian psychology = Psychologie canadienne · 2024Article
- Association of psychological resilience with all-cause and cause-specific mortality in older adults: a cohort study.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Although exposure to adversity increases risk for poor mental health outcomes, many people exposed to adversity do not develop such outcomes. Psychological resilience, defined broadly as positive emotional and/or behavioral adaptation to adversity, may be influenced by genetic factors that have remained largely unexplored in the era of large-scale genome-wide studies. In this perspective, we provide an integrative framework for studying human genome-wide variation underlying resilience. We first outline three complementary working definitions of psychological resilience-as a capacity, process, and outcome. For each definition, we review emerging empirical evidence, including findings from positive psychology, to illustrate how a resilience-based framework can guide novel and fruitful directions for the field of psychiatric genomics, distinct from the ongoing study of psychiatric risk and related traits. Finally, we provide practical recommendations for future genomic research on resilience, highlighting a need to augment cross-sectional findings with prospective designs that include detailed measurement of adversities and outcomes. A research framework that explicitly addresses resilience could help us to probe biological mechanisms of stress adaptation, identify individuals who may benefit the most from prevention and early intervention, and ascertain modifiable protective factors that mitigate negative outcomes even for those at high genetic risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.