ArticleScience (New York, N.Y.)2019
T cell-mediated regulation of the microbiota protects against obesity.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
200 citing papers in PubMed, 1 synthesis or guideline pooled it, 373 citations in OpenAlex.
- Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome-A Systematic Review.Nutrients · 2019Pooled it
- Trial
- Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.Nature medicine · 2020Trial
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- Divergent jejunal cis- and trans-eQTLs and their microbiome associations following a diet lacking mineral phosphorus supplements in laying hens.BMC genomics · 2026Article
- Unveiling novel macrophage-specific biomarkers in MASH through single-cell sequencing for diagnostic modeling.Journal of lipid research · 2026Article
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- Current Understanding of Probiotic Strains and Immune Function: From Gut Microbiota to Systemic Immunity.International journal of molecular sciences · 2026Review
- Lactobacillus Reuteri L81 Alleviates Intestinal Barrier Damage Induced by Escherichia Coli K99 in Mice by Modulating Gut Microbiota Composition and Metabolic Products.Probiotics and antimicrobial proteins · 2026Article
- Intestinal stearoyl-CoA desaturase-2 is highly expressed and nutritionally regulated but dispensable for energy balance.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Article
- Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self-Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial-Host Crosstalk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- High-fat diet-induced obesity-related hypertension via altered gut microbiota-mediated histone butyrylation.Science China. Life sciences · 2026Article
- Gut microbiota and metabolic disease risk in youth.Cell reports. Medicine · 2026Review
- Article
- Dietary fat disrupts a commensal-host lipid network that promotes metabolic health.Cell metabolism · 2026Article
- A novel solid beverage RLMCR prevents obesity-related metabolic disorders through the gut-adipose axis.Frontiers in nutrition · 2026Article
- Intestinal neutral ceramidase exacerbates MASH pathogenesis.eGastroenterology · 2026Article
- Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota.Frontiers in nutrition · 2026Article
- Integrated gut microbiome and serum lipidomics reveals microbial-lipid interactions for predicting incident metabolic syndrome: a nested case-control study.Frontiers in microbiology · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Charisse PetersenDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0003-4045-2610
Rickesha BellDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0002-0554-0730
Kendra A KlagDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Soh-Hyun LeeDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0001-6620-8961
Raymond SotoDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Arevik GhazaryanDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Kaitlin BuhrkeDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
H Atakan EkizDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0001-7718-6841
Kyla S OstDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0003-4101-2836
Sihem BoudinaDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4711-1109
Ryan M O'ConnellDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
James E CoxDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0002-5977-2350
Claudio J VillanuevaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9731-7463
W Zac StephensDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. zac.stephens@path.utah.edu june.round@path.utah.edu.ORCID 0000-0002-8072-9023
June L RoundDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. zac.stephens@path.utah.edu june.round@path.utah.edu.ORCID 0000-0002-7158-9874
University of Utah · US
Funding
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7MTRAINING PROGRAM IN GENETICST32GM007464 · NIGMS · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J., STANFIELD, GILLIAN · 1985 to 2020
$6.1MTraining Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0MInterdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8MDeveloping therapies to target the microbiotaDP2AT008746 · NCCIH · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2014 to 2014
$2.2MUtilizing TALEN technology to regulate human microRNA'sDP2GM111099 · NIGMS · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M · 2013 to 2013
$2.2MMicro RNAs and chronic, low-grade inflammationR01AG047956 · NIA · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M · 2015 to 2019
$1.7MDNA packaging and delivery by dsDNA virusesR01GM114817 · NIGMS · UNIVERSITY OF UTAH · PI CASJENS, SHERWOOD R. · 2014 to 2017
$1.5MInvestigate the Role of Micro-RNA 155 in Myeloid Development during InflammationR00HL102228 · NHLBI · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M · 2011 to 2013
$654kThe role of T cell intrinsic TLR signaling on host-commensal interactionsR56AI107090 · NIAID · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2013 to 2013
$350kExploring the mechanisms of T cell intrinsic TLR2 signaling on Treg functionK22AI095375 · NIAID · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2012 to 2013
$270kHIV VACCINE PRODUCTIONN01AI095375 · NIAID · SRI INTERNATIONAL · PI KUNG, ADA P · 1999 to 2000
$61kNCCIH NIH HHS DP2 AT008746NHLBI NIH HHS R00 HL102228NIAID NIH HHS K22 AI095375NIAID NIH HHS N01 AI095375NIAID NIH HHS R56 AI107090NIAID NIH HHS T32 AI055434NIA NIH HHS R01 AG047956NIDDK NIH HHS T32 DK091317NIGMS NIH HHS DP2 GM111099NIGMS NIH HHS R01 GM114817NIGMS NIH HHS T32 GM007464NIH HHS P40 OD010995Wellcome Trust
Abstract
The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we observed the development of age-associated metabolic syndrome (MetS). Expansion of
Indexed as
AnimalsAntibiosisClostridiumDesulfovibrioHost Microbial InteractionsIntestinal AbsorptionLipid MetabolismMetabolic SyndromeMiceMice, Mutant StrainsMicrobiotaMyeloid Differentiation Factor 88ObesityT-Lymphocytes, RegulatoryMyd88 protein, mouseMyeloid Differentiation Factor 88
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.