Evidence map›Paper›PMID 31350950›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2019

Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis.

Jamal Jafari-Nedooshan, Mansour Moghimi, Mohammad Zare, Naeimeh Heiranizadeh, Majid Morovati-Sharifabad, Mohamad Javad Akbarian-Bafghi, Mohammad Hossein Jarahzadeh, Hossein Neamatzadeh

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jamal Jafari-NedooshanDepartment of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mansour MoghimiDepartment of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email: moghimim1350@gmail.com
Mohammad ZareDepartment of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Naeimeh HeiranizadehDepartment of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Majid Morovati-SharifabadDepartment of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran.
Mohamad Javad Akbarian-BafghiBam University of Medical Sciences, Department of Healthcare Management, Bam, Iran.
Mohammad Hossein JarahzadehDepartment of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehMother and New Born Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRArdakan University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10) gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10 gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with 4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR= 1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However, there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk. Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G polymorphisms are not significantly associated with increased risk of lung cancer.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticPromoter Regions, GeneticHumansInterleukin-10Lung NeoplasmsPrognosisRisk FactorsIL10 protein, humanInterleukin-10interleukin 10Lung cancerMeta-analysisPolymorphism

Identifiers

PMID31350950
PMCPMC6745207
OpenAlexW2971371032

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.