Evidence map›Paper›PMID 31356236›Full record

ReviewCurrent opinion in lipidology2019

The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.

Pallavi Mukherjee, Arnab Chattopadhyay, Alan M Fogelman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in lipidology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pallavi MukherjeeDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Arnab Chattopadhyay
Alan M Fogelman
University of California, Los Angeles · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 1985 to 2019
$55.2M
Targeting the Enterocyte to Prevent Vascular InflammationR01HL148286 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 2019 to 2022
$2.3M
NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL148286
6 · The paper itself

Abstract

purpose of reviewTo discuss recent findings on the importance of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer. RECENT

findingsIntegrin β7 natural gut intraepithelial T cells modulated metabolism and accelerated atherosclerosis in mice. Reducing the generation of lysophospholipids in the small intestine mimicked bariatric surgery and improved diabetes. Enterocyte-specific knockdown of stearoyl-CoA desaturase-1 significantly improved dyslipidemia in LDL receptor null (Ldlr) mice fed a Western diet. Adding a concentrate of tomatoes transgenic for the apolipoprotein A-I mimetic peptide 6F to the chow of wild-type mice altered lipid metabolism in the small intestine, preserved Notch signaling and reduced tumor burden in mouse models. The phospholipid-remodeling enzyme Lpcat3 regulated intestinal stem cells and progenitor cells by stimulating cholesterol biosynthesis; increasing cholesterol in the diet or through genetic manipulation promoted tumorigenesis in Apc mice. SUMMARY: The small intestine is important for regulating metabolism and inflammation in animal models of both atherosclerosis and cancer.

Indexed as

1-Acylglycerophosphocholine O-AcyltransferaseAnimalsAtherosclerosisDisease Models, AnimalHumansInflammationIntegrin beta ChainsIntestine, SmallMiceNeoplasmsReceptors, LDLStearoyl-CoA Desaturase1-Acylglycerophosphocholine O-Acyltransferaseintegrin beta7Integrin beta ChainsLPCAT3 protein, mouseReceptors, LDLScd1 protein, mouseStearoyl-CoA Desaturase

Identifiers

PMID31356236
PMCPMC6953609
OpenAlexW2965124709

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.