SynthesisNature human behaviour2019
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature human behaviour, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.Genome biology · 2026Article
- Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals.Molecular psychiatry · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Proteomic prediction of disease largely reflects environmental risk exposure.medRxiv : the preprint server for health sciences · 2025Article
- Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization.Nutrients · 2025Article
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.Nature genetics · 2025Article
- Trans-ancestral rare variant association study with machine learning-based phenotyping for metabolic dysfunction-associated steatotic liver disease.Genome biology · 2025Article
- Article
- Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.Frontiers in psychiatry · 2025Article
- Article
- Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging.Communications biology · 2024Article
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.Addiction biology · 2024Article
- Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes.Genes, brain, and behavior · 2024Article
- The impact of smoking and alcohol consumption on rosacea: a multivariable Mendelian randomization study.Frontiers in public health · 2024Article
- Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation.The Journal of clinical investigation · 2023Article
- Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis.Scientific reports · 2023Article
- Large genetic analysis of alcohol resistance and tolerance reveals an inverse correlation and suggests 'true' tolerance mutants.bioRxiv : the preprint server for biology · 2023Article
- The Physiological and Pathological Role of Acyl-CoA Oxidation.International journal of molecular sciences · 2023Review
- Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse.Molecular psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
98 authors.
Evangelos Evangelou *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5488-2999
He Gao *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Congying Chu *Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Georgios Ntritsos *Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.ORCID http://orcid.org/0000-0002-6213-2901
Paul BlakeleyDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Andrew R ButtsMolecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Raha PazokiDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Hideaki SuzukiCentre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0410-6940
Fotios KoskeridisDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.ORCID http://orcid.org/0000-0002-1253-7556
Andrianos M YiorkasDepartment of Life Sciences, Brunel University London, London, UK.
Ibrahim KaramanDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-9341-8155
Joshua ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Qiang LuoInstitute of Science and Technology for Brain-Inspired Intelligence, MOE-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-0426-6039
Stefanie AeschbacherCardiology Division, University Hospital Basel, Basel, Switzerland.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Sebastian E BaumeisterInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Toni-Kim ClarkeDepartment of Psychiatry, University of Edinburgh, Edinburgh, UK.
Niki DimouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.ORCID http://orcid.org/0000-0003-1678-9328
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9672-2547
Katherine A KentistouCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5816-664X
Peter K JoshiCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2167-7470
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.ORCID http://orcid.org/0000-0001-8025-2897
Ilja M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Mia-Maria PeräläFolkhälsan Research Center, Helsinki, Finland.ORCID http://orcid.org/0000-0002-6349-6301
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
David PorteousGeneration Scotland, Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Scott M RatliffDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Samuli TuominenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jagadish VangipurapuInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-1103-0876
Alexis WoodDepartment of Pediatrics/Nutrition, Baylor College of Medicine, Houston, TX, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Bing YuHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Juha AuvinenCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Minna MännikköNorthern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland.
Lorenz RischInstitute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Juha VeijolaDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Alexandra I BlakemoreDepartment of Life Sciences, Brunel University London, London, UK.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Harry CampbellCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Catharina A HartmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Andrew C HeathDepartment of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Michael KühneCardiology Division, University Hospital Basel, Basel, Switzerland.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Andrew M McIntoshDepartment of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6721-153X
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Albertine J OldehinkelDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6993-6884
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4886-5084
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1661-2402
James F WilsonCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Daniel LevyFramingham Heart Study, Framingham, MA, USA.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-4275-9328
Jimmy D Bell *Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, UK.ORCID http://orcid.org/0000-0003-3804-1281
Paul M Matthews *Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1619-8328
Adrian Rothenfluh *Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-3813-5723
Sylvane Desrivières *Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Gunter Schumann *Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. gunter.schumann@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7740-6469
Paul Elliott *Department of Epidemiology and Biostatistics, Imperial College London, London, UK. p.elliott@imperial.ac.uk.ORCID http://orcid.org/0000-0002-7511-5684
Funding
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MControl of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4MMechanisms of alcohol-induced plasticitey mediated by Arf6R01AA026818 · NIAAA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2018 to 2022
$1.7MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MMedical Research Council G0700704Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/R023484/1Medical Research Council MR/R026505/1MRF_ MRF-058-0004-RG-DESRINHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01 AA026818NIBIB NIH HHS U54 EB020403NIDA NIH HHS R21 DA040439NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIMH NIH HHS R01 MH085772
Abstract
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d
Indexed as
AdultAgedAlcohol DrinkingAlcoholismBrainFemaleGenesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMental DisordersMiddle AgedNeuroimagingPolymorphism, Single Nucleotide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.