Evidence map›Paper›PMID 31362388›Full record

ArticleMolecules (Basel, Switzerland)2019

Aristoteline, an Indole-Alkaloid, Induces Relaxation by Activating Potassium Channels and Blocking Calcium Channels in Isolated Rat Aorta.

Fernando Romero, Javier Palacios, Ignacio Jofré, Cristian Paz, Chukwuemeka R Nwokocha, Adrián Paredes, Fredi Cifuentes

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. 9-Hydroxyaristoquinolone: A New Indole Alkaloid Isolated fromInternational journal of molecular sciences · 2025
    Article
  3. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
  4. Natural Compounds Purified from the Leaves ofInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. The Potency ofFrontiers in pharmacology · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Fernando RomeroVicerrectoría de Investigación y Postgrado, Programa de Doctorado en Ciencias Médicas, Universidad de la Frontera, Temuco 4780000, Chile. fernando.romero@ufrontera.cl.ORCID 0000-0001-8189-0954
Javier PalaciosLaboratorio de Bioquímica Aplicada, Departamento de Química y Farmacia, Facultad Ciencias de la Salud, Universidad Arturo Prat, Iquique 1110939, Chile. clpalaci@unap.cl.ORCID 0000-0002-7997-9295
Ignacio JofréLaboratorio de Neurociencias y Biología de Péptidos, Centro de Excelencia en Biotecnología de La Reproducción, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile.
Cristian PazLaboratorio de Productos Naturales y Descubrimiento de Fármacos, Departamento de Ciencias básicas, Universidad de La Frontera, Temuco 4811230, Chile.ORCID 0000-0002-4668-4984
Chukwuemeka R NwokochaDepartment of Basic Medical Sciences Physiology Section, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston 7, KGN, Jamaica (W.I.).ORCID 0000-0001-7092-9382
Adrián ParedesLaboratorio de Química Biológica, Instituto Antofagasta, Universidad de Antofagasta, Antofagasta 1270300, Chile.ORCID 0000-0003-3332-8582
Fredi CifuentesLaboratorio de Fisiología Experimental, Instituto Antofagasta, Universidad de Antofagasta, Antofagasta 1270300, Chile.ORCID 0000-0001-5922-8892
Universidad de La Frontera · CLUniversidad de Antofagasta · CLArturo Prat University · CLUniversity of the West Indies System · JM

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 21151406Universidad Antofagasta NEXER; Project [ANT1756]
6 · The paper itself

Abstract

Alkaloids derived from plants have shown great medicinal benefits, and are often reported for their use in cardiovascular disease management.

Indexed as

AlkaloidsAnimalsAorta, ThoracicCalcium Channel BlockersCalcium ChannelsChloratesEndothelium, VascularMolecular StructureNitric OxidePhenylephrinePotassium ChannelsProstaglandinsRatsVasodilationVasodilator AgentsAlkaloidsCalcium Channel BlockersCalcium ChannelsChlorateschloric acidNitric OxidePhenylephrinePotassium ChannelsProstaglandinsVasodilator AgentsAristotelinecalcium channelspotassium channelsratvascular activity

Identifiers

PMID31362388
PMCPMC6695676
OpenAlexW2966296918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.