Evidence map›Paper›PMID 31364377›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Targeted renal knockdown of Na

Saurav Ghimire, Selim Terhzaz, Pablo Cabrero, Michael F Romero, Shireen A Davies, Julian A T Dow

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Saurav GhimireInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Selim TerhzazInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Pablo CabreroInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Michael F RomeroDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Shireen A DaviesInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Julian A T DowInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-9595-5146
University of Glasgow · GBMayo Clinic · US

Funding

VISUALIZATION AND PATHOPHYSIOLOGY OF RENAL STONE PRECURSOR LESIONSU54DK100227 · NIDDK · MAYO CLINIC ROCHESTER · PI MCCOLLOUGH, CYNTHIA H · 2013 to 2017
$6.3M
Drosophila model of oxalate nephrolithiasisR01DK092408 · NIDDK · MAYO CLINIC ROCHESTER · PI DOW, JULIAN ALEXANDER, ROMERO, MICHAEL F. · 2012 to 2015
$837k
Biotechnology and Biological Sciences Research Council BB/L002647/1Medical Research Council MC_PC_17190NIDDK NIH HHS R01 DK092408NIDDK NIH HHS U54 DK100227
6 · The paper itself

Abstract

Nephrolithiasis is one of the most common kidney diseases, with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models.

Indexed as

AllopurinolAnimalsDisease Models, AnimalDrosophila melanogasterEnzyme InhibitorsGene Knockdown TechniquesMalpighian TubulesMicrofilament ProteinsMutationNephrolithiasisPhosphoproteinsSodium-Hydrogen ExchangersUric AcidAllopurinolEnzyme InhibitorsMicrofilament ProteinsmoesinPhosphoproteinssodium-hydrogen exchanger regulatory factorSodium-Hydrogen ExchangersUric AcidDrosophilaMalpighian tubulenephrolithiasissex-determining region Y protein-interacting protein-1uric acid stones

Identifiers

PMID31364377
PMCPMC6843049
OpenAlexW2965665877

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.