Evidence map›Paper›PMID 31365292›Full record

ArticleAmerican journal of physiology. Cell physiology2019

NHERF3 is necessary for

Tiane Chen, Ruxian Lin, Leela Avula, Rafiquel Sarker, Jianbo Yang, Boyoung Cha, Chung Ming Tse, George McNamara, Ursula Seidler, Scott Waldman and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. EnterotoxigenicInfection and immunity · 2022
    Article
  5. Review
  6. Article
  7. EnterotoxigenicGut microbes
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Tiane ChenDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ruxian LinDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Leela AvulaDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rafiquel SarkerDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jianbo YangDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Boyoung ChaDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chung Ming TseDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
George McNamaraDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-4155-0976
Ursula SeidlerDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Scott WaldmanDivision of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.
Adam SnookDivision of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0001-9216-4560
Marcel J C BijveldsDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Hugo R de JongeDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Xuhang LiDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mark DonowitzDepartments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USErasmus MC · NLThomas Jefferson University · USMedizinische Hochschule Hannover · DE

Funding

Project 3 - Human colonoids as a model for the pathobiology of EHECP01AI125181 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FOULKE-ABEL, JENNIFER, KAPER, JAMES B · 2016 to 2025
$18.6M
Two-Photon Microscopy Imaging CoreP01DK072084 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2006 to 2013
$12.7M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
DIARRHEAL DISEASES: A PHYSIOLOGIC APPROACH TO TREATMENTR01DK026523 · NIDDK · TUFTS MEDICAL CENTER · PI DONOWITZ, MARK · 1986 to 2016
$7.8M
PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
Olympus FluoView3000RS Confocal MicroscopeS10OD025244 · OD · JOHNS HOPKINS UNIVERSITY · PI O'ROURKE, BRIAN · 2018 to 2018
$448k
NIAID NIH HHS P01 AI125181NIDDK NIH HHS P01 DK072084NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK026523NIDDK NIH HHS R01 DK061765NIDDK NIH HHS R24 DK099803NIH HHS S10 OD025244
6 · The paper itself

Abstract

Enterotoxigenic

Indexed as

AnimalsBacterial ToxinsCaco-2 CellsCyclic GMPDiarrheaEnterotoxinsEscherichia coliEscherichia coli ProteinsHumansMembrane ProteinsMice, TransgenicSodium-Hydrogen Exchanger 3Bacterial ToxinsCyclic GMPEnterotoxinsEscherichia coli Proteinsheat stable toxin (E coli)Membrane ProteinsPDZK1 protein, humanPDZK1 protein, mouseSLC9A3 protein, humanSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3GC-Cguanylate cyclase Cheat-stable E. coli enterotoxin (ST)intracellular calciumNHE3NHERF3, NHERF2

Identifiers

PMID31365292
PMCPMC6850991
OpenAlexW2965653706

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.