Evidence map›Paper›PMID 31367922›Full record

SynthesisCurrent cardiology reports2019

Engineering Functional Cardiac Tissues for Regenerative Medicine Applications.

Martin L Tomov, Carmen J Gil, Alexander Cetnar, Andrea S Theus, Bryanna J Lima, Joy E Nish, Holly D Bauser-Heaton, Vahid Serpooshan

Abstract readSystematic Review
In one paragraph

Synthesis in Current cardiology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Patient-specific 3DFrontiers in cardiovascular medicine · 2024
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications.Frontiers in bioengineering and biotechnology · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin L TomovWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Carmen J GilWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Alexander CetnarWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Andrea S TheusWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Bryanna J LimaWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Joy E NishWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA.
Holly D Bauser-HeatonDivision of Pediatric Cardiology, Children's Healthcare of Atlanta Sibley Heart Center, Atlanta, GA, 30322, USA.
Vahid SerpooshanWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, 1760 Haygood Dr. NE, HSRB Bldg., Suite E480, Atlanta, GA, 30322, USA. vahid.serpoosahan@bme.gatech.edu.

Funding

Molecular and Cellular Mechanisms of Neonatal Cardiac Development and RepairR00HL127295 · NHLBI · EMORY UNIVERSITY · PI SERPOOSHAN, VAHID · 2018 to 2020
$729k
NHLBI NIH HHS R00 HL127295
6 · The paper itself

Abstract

purpose of reviewTissue engineering has expanded into a highly versatile manufacturing landscape that holds great promise for advancing cardiovascular regenerative medicine. In this review, we provide a summary of the current state-of-the-art bioengineering technologies used to create functional cardiac tissues for a variety of applications in vitro and in vivo. RECENT

findingsStudies over the past few years have made a strong case that tissue engineering is one of the major driving forces behind the accelerating fields of patient-specific regenerative medicine, precision medicine, compound screening, and disease modeling. To date, a variety of approaches have been used to bioengineer functional cardiac constructs, including biomaterial-based, cell-based, and hybrid (using cells and biomaterials) approaches. While some major progress has been made using cellular approaches, with multiple ongoing clinical trials, cell-free cardiac tissue engineering approaches have also accomplished multiple breakthroughs, although drawbacks remain. This review summarizes the most promising methods that have been employed to generate cardiovascular tissue constructs for basic science or clinical applications. Further, we outline the strengths and challenges that are inherent to this field as a whole and for each highlighted technology.

Indexed as

Biocompatible MaterialsBioprintingCell- and Tissue-Based TherapyHeartHumansMyocardiumMyocytes, CardiacPrinting, Three-DimensionalRegenerative MedicineTissue EngineeringTissue ScaffoldsTranslational Research, BiomedicalBiocompatible Materials3D modelingBioprintingCardiac tissue engineeringCardiovascular regenerative medicinePatient-specific precision medicineVascular network

Identifiers

PMID31367922
PMCPMC7153535

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.