Evidence map›Paper›PMID 31367973›Full record

ArticleHuman genetics2019

Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish.

Andrea R Waksmunski, Robert P Igo, Yeunjoo E Song, Jessica N Cooke Bailey, Renee Laux, Denise Fuzzell, Sarada Fuzzell, Larry D Adams, Laura Caywood, Michael Prough and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Andrea R WaksmunskiDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Robert P IgoDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Yeunjoo E SongDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jessica N Cooke BaileyCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Renee LauxDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Denise FuzzellDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Sarada FuzzellDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Larry D AdamsJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Laura CaywoodJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Michael ProughJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Dwight StambolianDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA.
William K ScottJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Jonathan L HainesDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. jonathan.haines@case.edu.
Case Western Reserve University · USUniversity of Miami · USDr. John T. Macdonald Foundation · USUniversity of Pennsylvania · US

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
NEI NIH HHS R01 EY023164NIH HHS EY023164PhRMA Foundation PhRMA Informatics Postdoctoral Fellowship
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in the world. While dozens of independent genomic variants are associated with AMD, about one-third of AMD heritability is still unexplained. To identify novel variants and loci for AMD, we analyzed Illumina HumanExome chip data from 87 Amish individuals with early or late AMD, 79 unaffected Amish individuals, and 15 related Amish individuals with unknown AMD affection status. We retained 37,428 polymorphic autosomal variants across 175 samples for association and linkage analyses. After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10

Indexed as

Genetic Predisposition to DiseaseGenetic VariationQuantitative Trait LociAgedAged, 80 and overAllelesAmishComputational BiologyFemaleGene FrequencyGene OntologyGenetic Association StudiesGenetic LinkageHumansIndianaMacular Degeneration

Identifiers

PMID31367973
PMCPMC6745026
OpenAlexW2966347847

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.