Evidence map›Paper›PMID 31367985›Full record

Trial reportSurgical endoscopy2020

Short-term improvements in cognitive function following vertical sleeve gastrectomy and Roux-en Y gastric bypass: a direct comparison study.

Kimberly R Smith, Timothy H Moran, Afroditi Papantoni, Caroline Speck, Arnold Bakker, Vidyulata Kamath, Susan Carnell, Kimberley E Steele

Open access · greenAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Brain effect of bariatric surgery in people with obesity.International journal of obesity (2005) · 2022
    Trial
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kimberly R SmithDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA. Kimberly.smith@jhmi.edu.
Timothy H MoranDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Afroditi PapantoniDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Caroline SpeckDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Arnold BakkerDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Vidyulata KamathDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Susan CarnellDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St., Phipps 316, Baltimore, MD, 21287, USA.
Kimberley E SteeleDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

NIDDK NIH HHS K23 DK100559
6 · The paper itself

Abstract

backgroundCognitive deficits are observed in individuals with obesity. While bariatric surgery can reverse these deficits, it remains unclear whether surgery type differentially influences cognitive outcome. We compared the extent to which vertical sleeve gastrectomy (VSG) and Roux-en Y gastric bypass (RYGB) ameliorated cognitive impairments associated with obesity.

methodsFemale participants approved for VSG (N = 18) or RYGB (N = 18) were administered cognitive measures spanning the domains of attention [Hopkins Verbal Learning Test (HVLT) Trial 1 and Letter Number Sequencing], processing speed [Stroop Color Trial, Symbol Digit Modalities Test, and Trail Making Part A], memory [HVLT Retained and HVLT Discrimination Index], and executive functioning (Stroop Color Word Trials and Trail Making Part B-A) prior to surgery and at 2 weeks and 3 months following surgery. Scores for each cognitive domain were calculated and compared between surgical cohorts using repeated measures analyses of variance.

resultsSignificant weight loss was observed 2 weeks and 3 months following RYGB and VSG and was accompanied by improvements in processing speed and executive functioning. Patients who received RYGB also experienced improved attention as early as 2 weeks, which persisted at 3 months. This was not observed in individuals who underwent VSG. No changes in memory were observed from baseline measures in either group.

conclusionsThis is the first report of cognitive improvements following VSG and the first direct comparison of cognitive improvements following RYGB and VSG. Short-term improvements in specific domains of cognitive function are observed at the beginning of the active weight loss phase following bariatric surgery that persisted to 3 months. The anatomical distinction between the two surgeries and resulting differential metabolic profiles may be responsible for the improvements in attention observed following RYGB but not following VSG.

Indexed as

CognitionAdultBariatric SurgeryBody Mass IndexExecutive FunctionFemaleGastrectomyGastric BypassHumansMaleObesityPostoperative PeriodWeight LossBariatric surgeryCognitionRoux-en Y gastric bypassVertical sleeve gastrectomy

Identifiers

PMID31367985
PMCPMC6992504
OpenAlexW2966547406

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.