ArticleActa diabetologica2020
Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus.
Article in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Relationship Between Physical Activity and Autonomic Responses in Adults with Type 2 Diabetes.International journal of environmental research and public health · 2025Observational
- Effect of Heart Rate Variability Biofeedback on Cardiac Autonomic Activation and Diabetes Self-Care in Patients with Type II Diabetes Mellitus.Applied psychophysiology and biofeedback · 2025Review
- Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesisWorld journal of gastroenterology · 2025Article
- Combined minimally invasive vagal cranial nerve and trigeminocervical complex peripheral nerve stimulation produces prolonged improvement of severe painful peripheral neuropathy and hyperglycemia in type 2 diabetes.Frontiers in neuroscience · 2025Article
- Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy.Cardiovascular research · 2023Review
- Heart rate variability in different sleep stages is associated with metabolic function and glycemic control in type 2 diabetes mellitus.Frontiers in physiology · 2023Article
- Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort.PloS one · 2023Article
- Fecal Bacterial Community and Metagenome Function in Asians with Type 2 Diabetes, According to Enterotypes.Biomedicines · 2022Article
- Heart rate thresholds for cardiovascular risk and sympathetic activation in the metabolic syndrome.Acta diabetologica · 2022Article
- Diabetes Affects the Relationship between Heart Rate Variability and Arterial Stiffness in a Gender-Specific Manner.Journal of clinical medicine · 2022Article
- Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases.Endocrinology · 2021Review
- High Fasting Glycemia Predicts Impairment of Cardiac Autonomic Control in Adults With Type 2 Diabetes: A Case-Control Study.Frontiers in endocrinology · 2021Observational
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
aimsPresent study observed the impact of blood glucose control on sympathetic and vagus functional status in type 2 diabetes mellitus (DM) patients through observing the association between glycosylated hemoglobin (HbA1c) level and sympathetic and vagus functional status detected by heart rate recovery (HRR) and heart rate variability (HRV) assessments.
methodsConsecutive hospitalized DM patients were divided into well glycemic control group (HbA1c < 7.0%, group WGC, n = 100) and poor glycemic control group (HbA1c ≥ 7.0%, group PGC, n = 100), 100 hospitalized patients without DM served as control group (group C). All subjects underwent blood biochemistry test, treadmill exercise testing and 24-h Holter monitoring.
resultsHRR and HRV parameters were significantly lower in group WGC and PGC than in group C. Standard deviation of NN intervals (SDNN), standard deviation of all 5-min average NN intervals (SDANN), very low frequency (VLF) values were significantly lower in group PGC than in group WGC. HbA1c level was negatively correlated with HRR1, SDNN, SDANN, VLF, low frequency and high frequency. Logistic regression analysis showed that lower SDNN, SDANN and VLF values were risk factors for high HbA1c levels in DM patients after adjusting for gender, age and beta-blocker use in the model 1, and for gender, age, beta-blocker use, coronary artery disease and hypertension in the model 2.
conclusionsPresent results indicate that sympathetic and vagal functional status are impaired independent of HbA1c level, while poor glycemic control is related to more significant neurocardiac dysfunction in DM patients.
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