Evidence map›Paper›PMID 31375072›Full record

ArticleBMC nephrology2019

Effect of hemodialysis on extracellular vesicles and circulating submicron particles.

Marcel Ruzicka, Fengxia Xiao, Hussein Abujrad, Yasamin Al-Rewashdy, Vera A Tang, Marc-André Langlois, Alexander Sorisky, Teik Chye Ooi, Dylan Burger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Extracellular vesicles in cancer therapy.Seminars in cancer biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Marcel RuzickaKidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, 2513-451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada. mruzicka@toh.ca.
Fengxia XiaoKidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, 2513-451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.
Hussein AbujradDivision of Endocrinology and Metabolism, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Yasamin Al-RewashdyDivision of Endocrinology and Metabolism, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Vera A TanguOttawa Flow Cytometry & Virometry Core Facility, Ottawa, Ontario, Canada.
Marc-André LangloisuOttawa Flow Cytometry & Virometry Core Facility, Ottawa, Ontario, Canada.
Alexander SoriskyDivision of Endocrinology and Metabolism, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Teik Chye OoiDivision of Endocrinology and Metabolism, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Dylan BurgerKidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, 2513-451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada. dburger@uottawa.ca.ORCID 0000-0003-3951-2911
University of Ottawa · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundAlthough hemodialysis is a highly effective treatment for diffusive clearance of low molecular weight uremic toxins, its effect on circulating extracellular vesicles and submicron particles is less clear. The purpose of this study was to examine the impact of hemodialysis on circulating levels of submicron particles.

methodsPlasma samples from patients were collected immediately before and after the mid-week hemodialysis session. Total submicron particles were assessed by nanoparticle tracking analysis and levels of endothelial (CD144

resultsTotal submicron particle number was significantly lower post-dialysis with reductions in particles < 40 nm, 40-100 nm, and 100-1000 nm in size. Circulating annexin V

conclusionsIn summary, hemodialysis is associated with reductions in circulating submicron particles including membrane MPs. Accordingly, there may be significant interdialytic variation in circulating submicron particles. Investigators interested in measuring extracellular vesicles in patients undergoing hemodialysis should therefore carefully consider the timing of biosampling.

Indexed as

Extracellular VesiclesRenal DialysisAnnexin A5Antigens, CDBlood PlateletsCadherin 5CadherinsCell-Derived MicroparticlesCohort StudiesFemaleFlow CytometryHemodialysis SolutionsHumansKidney Failure, ChronicLeukocyte Common AntigensLeukocytesAnnexin A5Antigens, CDCadherin 5CadherinsHemodialysis SolutionsLeukocyte Common AntigensPTPRC protein, humanDialysisEndotheliumEnd stage kidney diseaseExtracellular vesicleHemodialysisKidneyLeukocyteMicroparticlePlatelet

Identifiers

PMID31375072
PMCPMC6679543
OpenAlexW2966403310

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.