ArticleCancer cell2019
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cancer cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- PRKCI-ECT2 copy number gain promotes developmental reprogramming and metastatic competence in lung adenocarcinoma.Cell reports · 2026Article
- Comprehensive analysis of malignant subtypes of lung adenocarcinoma based on multi-omics landscape and functional validation of prognostic biomarker BAIAP2L2.Scientific reports · 2025Article
- Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma.Cell reports · 2025Article
- Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling.Cell communication and signaling : CCS · 2025Article
- Oncogenic Mutations and the Tumor Microenvironment: Drivers of Non-Small Cell Lung Cancer Progression.Cancers · 2025Review
- The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations.The Journal of biological chemistry · 2024Review
- NucleariScience · 2024Article
- MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells.Cancer cell international · 2023Review
- RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.Cancer research communications · 2023Article
- Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.Trends in cell biology · 2022Review
- Protein kinase Cι mediates immunosuppression in lung adenocarcinoma.Science translational medicine · 2022Article
- WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer.Cancer research · 2022Article
- TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer.International journal of molecular sciences · 2022Review
- Lung Cancer Stem Cells and Their Clinical Implications.Cold Spring Harbor perspectives in medicine · 2022Review
- Review
- CircRNAs: Roles in regulating head and neck squamous cell carcinoma.Frontiers in oncology · 2022Review
- Machine learning reveals two heterogeneous subtypes to assist immune therapy based on lipid metabolism in lung adenocarcinoma.Frontiers in immunology · 2022Article
- Deep learning reveals cuproptosis features assist in predict prognosis and guide immunotherapy in lung adenocarcinoma.Frontiers in endocrinology · 2022Article
- Protein kinase CCell reports · 2021Article
- KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer.Oncogene · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 2 countries.
Ning YinDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Yi LiuDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Andras KhoorDepartment of Pathology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.
Xue WangDepartment of Health Sciences Research, Mayo Clinic Florida, Jacksonville, FL 32224, USA.
E Aubrey ThompsonDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Michael LeitgesMemorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.
Verline JustilienDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Capella WeemsDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Nicole R MurrayDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA.
Alan P FieldsDepartment of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Griffin Cancer Research Building, Room 212, Jacksonville, FL 32224, USA. Electronic address: fields.alan@mayo.edu.
Mayo Clinic in Florida · USMemorial University of Newfoundland · CA
Funding
Three-Dimensional Organoid Cultures to Investigate 3q26 Driver Functions in Multiple Lung Cancer Cells of OriginR01CA081436 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI FIELDS, ALAN P. · 1999 to 2022
$9.9MTherapeutic targeting of Kras-driven Lung AdenocarcinomaR01CA206367 · NCI · MAYO CLINIC JACKSONVILLE · PI FIELDS, ALAN P. · 2016 to 2020
$1.8MRole of PKC iota in metaplasia and initiation of pancreatic cancerR01CA140290 · NCI · MAYO CLINIC JACKSONVILLE · PI MURRAY, NICOLE R · 2011 to 2015
$1.6MNCI NIH HHS R01 CA081436NCI NIH HHS R01 CA140290NCI NIH HHS R01 CA206367
Abstract
We report that mouse LSL-Kras
Indexed as
Genes, rasWnt Signaling PathwayAdenocarcinoma of LungAlveolar Epithelial CellsAnimalsAntineoplastic Agentsbeta CateninCell Line, TumorCell ProliferationCell Transformation, NeoplasticFemaleGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansIsoenzymesLung NeoplasmsAntineoplastic Agentsbeta CateninCTNNB1 protein, humanCTNNB1 protein, mouseIsoenzymesProtein Kinase CProtein Kinase C-lambdaProtein Kinase InhibitorsTP53 protein, humanTrp53 protein, mouseTumor Suppressor Protein p53alveolar type 2 cellsbronchoalveolar stem cellsKras/Trp53 transformationlung adenocarcinoma molecular subtypeslung cancerprotein kinase Cι signalingtherapeutic vulnerabilityWnt signaling
Identifiers
What Socratic holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.