Evidence map›Paper›PMID 31378979›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2019

MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Bérénice A Benayoun, Changhan Lee

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Changhan LeeLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0003-0327-4712
University of Southern California · US

Funding

Novel Regulators of Aging Metabolism Encoded in the Mitochondrial GenomeR01AG052558 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, CHANGHAN · 2016 to 2020
$1.8M
Regulation of transcriptional consistency by broad H3K4me3 domains in young cells and during agingR00AG049934 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2017 to 2019
$717k
NIA NIH HHS R00 AG049934NIA NIH HHS R01 AG052558
6 · The paper itself

Abstract

Mitochondria are increasingly being recognized as information hubs that sense cellular changes and transmit messages to other cellular components, such as the nucleus, the endoplasmic reticulum (ER), the Golgi apparatus, and lysosomes. Nonetheless, the interaction between mitochondria and the nucleus is of special interest because they both host part of the cellular genome. Thus, the communication between genome-bearing organelles would likely include gene expression regulation. Multiple nuclear-encoded proteins have been known to regulate mitochondrial gene expression. On the contrary, no mitochondrial-encoded factors are known to actively regulate nuclear gene expression. MOTS-c (mitochondrial open reading frame of the 12S ribosomal RNA type-c) is a recently identified peptide encoded within the mitochondrial 12S ribosomal RNA gene that has metabolic functions. Notably, MOTS-c can translocate to the nucleus upon metabolic stress (e.g., glucose restriction and oxidative stress) and directly regulate adaptive nuclear gene expression to promote cellular homeostasis. It is hypothesized that cellular fitness requires the coevolved mitonuclear genomes to coordinate adaptive responses using gene-encoded factors that cross-regulate the opposite genome. This suggests that cellular gene expression requires the bipartite split genomes to operate as a unified system, rather than the nucleus being the sole master regulator.

Indexed as

AnimalsCell NucleusEpistasis, GeneticEukaryotic CellsGene Expression RegulationGenomeHumansIntracellular Signaling Peptides and ProteinsMitochondriaMitochondrial ProteinsRNA, RibosomalhumaninIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsMOTS-c peptide, humanRNA, RibosomalRNA, ribosomal, 12Sgene regulationmetabolismmitochondriamitochondrial-derived peptidesmitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c)mitonuclear communicationstress responses

Identifiers

PMID31378979
PMCPMC8224472
OpenAlexW2965245802

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.