ArticleExperimental gerontology2019
Dose-dependent association of accelerometer-measured physical activity and sedentary time with brain perfusion in aging.
Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Sedentary behavior, cognition, and brain health in older adults: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Total Sedentary Time and Cognitive Function in Middle-Aged and Older Adults: A Systematic Review and Meta-analysis.Sports medicine - open · 2022Pooled it
- Voluntary Long-Term Exercise by Female Mice Modulates Anxiety-Like Behavior and Motor Function but Minimally Impacts Acute Oxidative Injury in the Central Nervous System.The European journal of neuroscience · 2025Article
- Physical activity as a modifiable risk factor in preclinical Alzheimer's disease.Nature medicine · 2025Article
- Characterizing Gray matter atrophy patterns associated with accelerometer-measured sedentary behavior: a population-based study.Brain imaging and behavior · 2025Article
- Modeling the importance of life exposure factors on memory performance in diverse older adults: A machine learning approach.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Feasibility and Cultural Adaptation of a Community-Engaged Physical Activity Intervention for Hispanic Older Adults: Pilot Study.JMIR formative research · 2025Article
- Article
- Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.Journal of medical Internet research · 2024Article
- Sedentary behavior and lifespan brain health.Trends in cognitive sciences · 2024Review
- Exercise and Protection from Age-Related Cognitive Decline.Current topics in behavioral neurosciences · 2024Review
- Greater subjective cognitive decline severity is associated with worse memory performance and lower entorhinal cerebral blood flow in healthy older adults.Journal of the International Neuropsychological Society : JINS · 2024Article
- The Combined Impact of Physical Activity and Sedentary Behavior on Executive Functions in Older Adults: A Cross-Sectional Study.Psychology research and behavior management · 2024Article
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- Examining sex differences in the association between sedentary behavior and cognitive function in bariatric surgery patients.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
- Associations between everyday activities and arterial spin labeling-derived cerebral blood flow: A longitudinal study in community-dwelling elderly volunteers.Human brain mapping · 2023Article
- The Physiological and Molecular Links Between Physical Activity and Brain Health: A Review.Neuroscience insights · 2023Review
- Orthostatic intolerance: a handicap of aging or physical deconditioning?European journal of applied physiology · 2022Review
- Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults.Neurobiology of aging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionAge-related decreases in cerebral blood flow (CBF) may lead to cognitive decline, while physical activity (PA) can maintain CBF and cognition in aging. The intensity of PA needed to affect CBF in aging, and the independent effects of sedentary time on CBF are currently unknown. Moreover, research conducted in free-living environments with objective measures of PA (e.g., accelerometry) is lacking.
methodsThis cross-sectional study used accelerometry to objectively measure sedentary time, all light PA [AllLightPA], moderate-to-vigorous PA [MVPA], and total activity counts [TAC] in 52 cognitively healthy older adults. Robust linear regressions investigated the association of CBF (using arterial spin labeling magnetic resonance imaging) in frontal and medial temporal regions, with each PA intensity and sedentary time.
resultsGreater sedentary time was significantly associated with lower CBF in lateral and medial frontal regions after adjusting for MVPA, while higher AllLightPA (adjusted for MVPA), MVPA (adjusted for AllLightPA), and TAC were associated with greater CBF in lateral and medial frontal regions. DISCUSSION: Lighter activities, as well as MVPA, are beneficial to CBF in brain regions typically affected by the aging process and malleable to exercise interventions (i.e., the frontal lobes), whereas sedentary time is an independent risk factor for neurovascular dysregulation in normal aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.