Evidence map›Paper›PMID 31383376›Full record

ReviewTrends in pharmacological sciences2019

Artificial Intelligence for Drug Toxicity and Safety.

Anna O Basile, Alexandre Yahi, Nicholas P Tatonetti

Abstract readReview
In one paragraph

Review in Trends in pharmacological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Leveraging AI for cell biology discovery.Biochemical Society transactions · 2026
    Review
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna O BasileColumbia University Medical Center, New York, NY, USA.
Alexandre YahiColumbia University Medical Center, New York, NY, USA.
Nicholas P TatonettiColumbia University Medical Center, New York, NY, USA. Electronic address: nick.tatonetti@columbia.edu.

Funding

Precision Pharmacology and Pharmacovigilance: Leveraging AI to address drug safety knowledge gapsR35GM131905 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas P Tatonetti · 2019 to 2026
$3.3M
Biomedical Data Translator Technical Feasibility Assessment and Architecture DesignOT3TR002027 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DUMONTIER, MICHEL, TATONETTI, NICHOLAS P · 2016 to 2019
$2.7M
Drug Effect Discovery Through Data Mining and Integrative Chemical BiologyR01GM107145 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TATONETTI, NICHOLAS P · 2014 to 2018
$2.5M
NCATS NIH HHS OT3 TR002027NIGMS NIH HHS R01 GM107145NIGMS NIH HHS R35 GM131905
6 · The paper itself

Abstract

Interventional pharmacology is one of medicine's most potent weapons against disease. These drugs, however, can result in damaging side effects and must be closely monitored. Pharmacovigilance is the field of science that monitors, detects, and prevents adverse drug reactions (ADRs). Safety efforts begin during the development process, using in vivo and in vitro studies, continue through clinical trials, and extend to postmarketing surveillance of ADRs in real-world populations. Future toxicity and safety challenges, including increased polypharmacy and patient diversity, stress the limits of these traditional tools. Massive amounts of newly available data present an opportunity for using artificial intelligence (AI) and machine learning to improve drug safety science. Here, we explore recent advances as applied to preclinical drug safety and postmarketing surveillance with a specific focus on machine and deep learning (DL) approaches.

Indexed as

Adverse Drug Reaction Reporting SystemsArtificial IntelligenceAnimalsDrug Evaluation, PreclinicalDrug-Related Side Effects and Adverse ReactionsHumansMachine LearningPharmacovigilanceProduct Surveillance, PostmarketingQuantitative Structure-Activity RelationshipToxicity Testsadverse drug reactionsdeep learningmachine learningpharmacovigilance

Identifiers

PMID31383376
PMCPMC6710127

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.