Evidence map›Paper›PMID 31384734›Full record

ArticleVaccine: X2019

Antigen delivery format variation and formulation stability through use of a hybrid vector.

Marie Beitelshees, Andrew Hill, Yi Li, Mingfu Chen, Mahmoud Kamal Ahmadi, Randall J Smith, Stelios T Andreadis, Pooya Rostami, Charles H Jones, Blaine A Pfeifer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Marie BeitelsheesDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Andrew HillDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Yi LiDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Mingfu ChenDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Mahmoud Kamal AhmadiDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Randall J SmithDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Stelios T AndreadisDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
Pooya RostamiAbcombi Biosciences Inc., Buffalo, NY 14260-4200, USA.
Charles H JonesAbcombi Biosciences Inc., Buffalo, NY 14260-4200, USA.
Blaine A PfeiferDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200, USA.
University at Buffalo, State University of New York · USAbcombi Biosciences (United States) · US

Funding

A Hybrid Bio-synthetic Vector Designed to Elicit Directed in vivo Immune ResponseR21AI117309 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PFEIFER, BLAINE A. · 2016 to 2017
$435k
A Hybrid Biomaterial-biological Vector for Antigen Presenting Cell Gene DeliveryR03AI088485 · NIAID · TUFTS UNIVERSITY MEDFORD · PI PFEIFER, BLAINE A. · 2010 to 2011
$145k
NIAID NIH HHS R03 AI088485NIAID NIH HHS R21 AI117309
6 · The paper itself

Abstract

A hybrid biological-biomaterial antigen delivery vector comprised of a polymeric shell encapsulating an

Indexed as

APCs, antigen presenting cellsAS, aqueous storageCDM, chemically defined bacterial growth mediumCFA, Complete Freund's AdjuvantCHV, cytoplasmic hybrid vectorClyA, cytolysin ACPSs, capsular polysaccharidesDNA vaccineDS, desiccated storageEHV, empty hybrid vectorIN, intranasalIP, intraperitonealLBVs, live bacterial vectorsLLO, listeriolysin ONVT, non-vaccine typePAMPs, pathogen-associated molecular patternsPcpA, pneumococcal choline-binding protein APCVs, pneumococcal conjugate vaccinesPhtD, histidine triad protein DPHV, periplasmic hybrid vectorpHV, plasmid hybrid vectorPneumococcal diseasePneumococcal surface protein A (PspA)PspA, pneumococcal surface protein ASC, subcutaneousSHV, surface hybrid vectorStreptococcus pneumoniaeVaccine delivery

Identifiers

PMID31384734
PMCPMC6668244
OpenAlexW2913316603

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.