Evidence map›Paper›PMID 31385064›Full record

ArticleEuropean journal of nutrition2020

Early weaning alters the thermogenic capacity of brown adipose tissue in adult male and female rats.

T C Peixoto, C B Pietrobon, I M Bertasso, F A H Caramez, C Calvino, T R Santos, E Oliveira, E G Moura, P C Lisboa

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Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

T C PeixotoDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
C B PietrobonDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
I M BertassoDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
F A H CaramezDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
C CalvinoDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
T R SantosDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
E OliveiraDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
E G MouraDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
P C LisboaDepartamento de Ciências Fisiológicas, 5º andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil. pclisboa@uerj.br.ORCID http://orcid.org/0000-0002-2477-4364
Universidade do Estado do Rio de Janeiro · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

purposeEarly weaning (EW) is a risk factor for obesity development. Brown adipose tissue (BAT) hypofunction is related to obesity onset. Here, we evaluated whether sympathetic nervous system (SNS) activity in BAT and the thermogenic function of BAT are decreased in adulthood in obese rats from two EW models.

methodsAt the time of birth, lactating Wistar rats and their pups (three males and three females) were separated into three groups: the control group, in which pups consumed milk throughout lactation; the non-pharmacological EW (NPEW) group, in which suckling was interrupted with a bandage during the last 3 days of lactation; and the pharmacological EW (PEW) group, in which dams were treated with bromocriptine (0.5 mg/twice a day) 3 days before weaning. The offspring were sacrificed on PN180.

resultsAdult male rats from both EW models exhibited lower BAT SNS activity. Female rats from the PEW group showed a decrease in BAT SNS activity. The protein levels of UCP1 were lower in the NPEW males, while PGC1α levels were lower in both PEW and NPEW males. Both groups of EW females showed reductions in the levels of β3-AR, TRβ1, and PGC1α. The UCP1 protein level was reduced only in the NPEW females. The EW groups of both sexes had lower AMPK protein levels in BAT. In the hypothalamus, only the PEW females showed an increase in AMPK protein levels. In both groups of EW males, adrenal catecholamine was increased and tyrosine hydroxylase was decreased, while in EW females, adrenal catecholamine was decreased.

conclusionsEarly weaning alters the thermogenic capacity of BAT, which partially contributes to obesity in adulthood, and there are sex-related differences in these alterations.

Indexed as

Adipose Tissue, BrownLactationAnimalsFemaleMaleRatsRats, WistarThermogenesisWeaningAutonomic functionBreastfeedingBromocriptineDevelopmental plasticityEarly weaningMetabolic syndrome

Identifiers

PMID31385064
OpenAlexW2965503543

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.