ArticleThe Journal of nutrition2019
A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults.
Article in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03356340 (The Singapore Chinese Health Study), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Singapore Chinese Health Study
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Identification of Chinese dietary patterns and their relationships with health outcomes: a systematic review and meta-analysis.Public health nutrition · 2024Pooled it
- Differential associations of diet with hepatic and muscle insulin resistance: insights from an dietary pattern analysis in the PERSON study.European journal of nutrition · 2026Observational
- Associations between Dietary Pattern Networks Derived from Machine Learning Algorithms and Cardiovascular Disease Risk in the NutriNet-Santé Cohort.The Journal of nutrition · 2025Observational
- Dietary patterns associated with benign breast nodules by subtypes: a cross-sectional study in southeast China.Frontiers in nutrition · 2025Article
- Dietary insulin index, dietary insulin load and dietary patterns and the risk of metabolic syndrome in Hoveyzeh Cohort Study.Scientific reports · 2024Article
- Dietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study.Frontiers in nutrition · 2024Article
- Comparison of data-driven identified hypertension-protective dietary patterns among Chinese adults: based on a nationwide study.European journal of nutrition · 2023Article
- Associations between an obesity-related dietary pattern and incidence of overall and site-specific cancers: a prospective cohort study.BMC medicine · 2023Article
- An Oxylipin-Related Nutrient Pattern and Risk of Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).Nutrients · 2023Article
- Association between dietary omega-3 intake and coronary heart disease among American adults: The NHANES, 1999-2018.PloS one · 2023Article
- Association between a dietary pattern high in saturated fatty acids, dietary energy density, and sodium with coronary heart disease.Scientific reports · 2022Article
- Article
- Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population.Nutrients · 2022Article
- The Prospective Associations of Lipid Metabolism-Related Dietary Patterns with the Risk of Diabetes in Chinese Adults.Nutrients · 2022Article
- Data-Driven Dietary Patterns, Nutrient Intake and Body Weight Status in a Cross-Section of Singaporean Children Aged 6-12 Years.Nutrients · 2021Article
- Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women.Nutrients · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCombinations of circulating fatty acids may affect the risk of type 2 diabetes (T2D) and coronary artery disease (CAD). No previous studies have identified a dietary pattern predicting fatty acid profiles using reduced rank regression (RRR) and evaluated its associations with the risk of T2D and CAD.
objectiveThe aim of this study was to derive a dietary pattern to explain variation in plasma fatty acid concentrations using RRR and evaluate these in relation to risk of T2D and CAD.
methodsWe derived a dietary pattern using fatty acid concentrations from 711 controls of a nested case-control study in the Singapore Chinese Health Study using RRR with 36 food and beverages as predictors and 19 fatty acid biomarkers as responses. Dietary pattern scores were then calculated for the full cohort of men and women (mean age: 56 y). We followed up 45,411 and 58,065 participants for incident T2D and CAD mortality, respectively. Multivariable Cox regression models were used to estimate HRs and 95% CIs.
resultsWe identified a dietary pattern high in soy, vegetables, fruits, tea, tomato products, bread, fish, margarine and dairy, and low in rice, red meat, coffee, alcohol, sugar-sweetened beverages, and eggs. This pattern predicted higher circulating n-3 (ω-3) PUFAs (18:3n-3, 20:3n-3, 20:5n-3), odd-chain fatty acids (15:0, 17:0), 18:2n-6 and 20:1, and lower 20:4n-6 and 16:1. During a mean follow-up of 11 y and 19 y, 5207 T2D and 3016 CAD mortality events, respectively, were identified. Higher dietary pattern scores were associated with a lower risk of T2D [multivariable-adjusted HR comparing extreme quintiles, 0.86 (95% CI: 0.79, 0.95); P-trend <0.001] and CAD mortality [HR, 0.76 (95% CI: 0.68, 0.86); P-trend <0.001].
conclusionsDietary patterns reflecting higher circulating n-3 PUFAs, odd-chain fatty acids, and linoleic acid may be associated with lower T2D and CAD risk in Chinese adults. This trial was registered at www.clinicaltrials.gov as NCT03356340.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.