ArticleScientific reports2019
European propolis is highly active against trypanosomatids including Crithidia fasciculata.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Therapeutic Potential of Propolis and Royal Jelly in Encephalitozoon Intestinalis Infection: An in Vitro Study.Acta parasitologica · 2025Article
- Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Cell wall disruption, membrane damage, and decrease in the expression of Yrp1 virulence factor inIranian journal of microbiology · 2023Article
- The Activity of Red Nigerian Propolis and Some of Its Components againstMolecules (Basel, Switzerland) · 2023Article
- Wheat Germ Oil and Propolis Decrease Parasite Burden and Restore Marked Histopathological Changes in Liver and Lung in Mice with Chronic Toxoplasmosis.Animals : an open access journal from MDPI · 2022Article
- Antineoplastic and Antitrypanosomal Properties of Propolis fromMolecules (Basel, Switzerland) · 2022Article
- The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes.Molecules (Basel, Switzerland) · 2022Article
- Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties.Antibiotics (Basel, Switzerland) · 2021Review
- Activity of Compounds from Temperate Propolis againstMolecules (Basel, Switzerland) · 2021Article
- Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review.Foods (Basel, Switzerland) · 2021Review
- Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties.Scientific reports · 2021Article
- Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil.Frontiers in pharmacology · 2021Article
- Determination of Total Phenolics, Flavonoids, and Antioxidant Activity and GC-MS Analysis of Malaysian Stingless Bee Propolis Water Extracts.Scientifica · 2021Article
- Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples.International journal for parasitology. Drugs and drug resistance · 2020Article
- The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.Molecules (Basel, Switzerland) · 2020Review
- Propolis as a novel antibacterial agent.Saudi journal of biological sciences · 2020Review
- Recent Advances Regarding the Phytochemical and Therapeutic Uses ofPlants (Basel, Switzerland) · 2020Review
- Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages.Metabolites · 2020Article
- Drug combinations as effective anti-leishmanials against drug resistantRSC medicinal chemistry · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana. The extracts were also tested against Crithidia fasciculata a close relative of Crithidia mellificae, a parasite of bees. Crithidia, Trypanosoma and Leishmania are all members of the order Kinetoplastida. High levels of activity were obtained for all the samples with the levels of activity varying across the sample set. The highest levels of activity were found against L. mexicana. The propolis samples were profiled by using liquid chromatography with high resolution mass spectrometry (LC-MS) and principal components analysis (PCA) of the data obtained indicated there was a wide variation in the composition of the propolis samples. Orthogonal partial least squares (OPLS) associated a butyrate ester of pinobanksin with high activity against T. brucei whereas in the case of T. congolense high activity was associated with methyl ethers of chrysin and pinobanksin. In the case of C. fasciculata highest activity was associated with methyl ethers of galangin and pinobanksin. OPLS modelling of the activities against L. mexicana using the mass spectrometry produced a less successful model suggesting a wider range of active components.
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