Evidence map›Paper›PMID 31399546›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The Hsp70 chaperone is a major player in stress-induced transposable element activation.

Ugo Cappucci, Fabrizia Noro, Assunta Maria Casale, Laura Fanti, Maria Berloco, Angela Alessandra Alagia, Luigi Grassi, Loredana Le Pera, Lucia Piacentini, Sergio Pimpinelli

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

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  16. Hsp70 and Hsp90 Elaborately Regulate RNAi Efficiency inInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ugo CappucciIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Fabrizia NoroIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Assunta Maria CasaleIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Laura FantiIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Maria BerlocoDepartment of Biology, University of Bari Aldo Moro, 70121 Bari, Italy.
Angela Alessandra AlagiaIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Luigi GrassiDepartment of Physics, Sapienza University of Rome, 00185 Rome, Italy.
Loredana Le PeraInstitute of Molecular Biology and Pathology, National Research Council, 00185 Rome, Italy.
Lucia PiacentiniIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy; lucia.piacentini@uniroma1.it sergio.pimpinelli@uniroma1.it.ORCID 0000-0002-3656-5068
Sergio PimpinelliIstituto Pasteur Italia, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00185 Rome, Italy; lucia.piacentini@uniroma1.it sergio.pimpinelli@uniroma1.it.ORCID 0000-0003-0838-9391
Istituto Pasteur · ITInstitute of Molecular Biology and Pathology · ITSapienza University of Rome · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that heat shock stress may activate transposable elements (TEs) in

Indexed as

DNA Transposable ElementsStress, PhysiologicalTranscriptional ActivationEvolution, MolecularGene SilencingHeat-Shock ResponseHSP70 Heat-Shock ProteinsModels, BiologicalProtein BindingRNA InterferenceDNA Transposable ElementsHSP70 Heat-Shock ProteinsevolutionHsp70transposable elements

Identifiers

PMID31399546
PMCPMC6731680
OpenAlexW2967015419

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.