Evidence map›Paper›PMID 31399956›Full record

SynthesisHeart failure reviews2020

Effects of exercise training in heart failure with preserved ejection fraction: an updated systematic literature review.

Massimo Leggio, Augusto Fusco, Claudia Loreti, Giorgio Limongelli, Maria Grazia Bendini, Andrea Mazza, Daniele Coraci, Luca Padua

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04307823 (Effects of Respiratory Muscles Training on Cardiopulmonary Parameters and Quality of Life in Patients With Dilated Cardiomyopathy), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04307823 nacompletednot on this map

Effects of Respiratory Muscles Training on Cardiopulmonary Parameters and Quality of Life in Patients With Dilated Cardiomyopathy

TypeinterventionalSponsorRiphah International UniversityRan2019 to 2020Enrolled22ConditionsDilated CardiomyopathyArmsTreadmill training, Treadmill protocol and Respiratory training
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Massimo Leggio *Department of Medicine and Rehabilitation, Cardiac Rehabilitation Operative Unit, San Filippo Neri Hospital, Rome, Italy.
Augusto Fusco *IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Claudia LoretiIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Giorgio LimongelliDepartment of Medicine and Rehabilitation, Cardiac Rehabilitation Operative Unit, San Filippo Neri Hospital, Rome, Italy.
Maria Grazia BendiniCardiology Division, Santa Maria della Stella Hospital, Orvieto, Italy.
Andrea MazzaCardiology Division, Santa Maria della Stella Hospital, Orvieto, Italy.
Daniele CoraciFondazione Policlinico Universitario A. Gemelli IRCCS, L.go F. Vito, 1, 00168, Rome, Italy. danielecoraci@aol.com.ORCID http://orcid.org/0000-0002-7019-9006
Luca PaduaFondazione Policlinico Universitario A. Gemelli IRCCS, L.go F. Vito, 1, 00168, Rome, Italy.
Don Carlo Gnocchi Foundation · ITOspedale San Filippo Neri · ITAgostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity is associated with a lower risk of adverse cardiovascular outcomes, including heart failure (HF). Exercise training is a class IA level recommendation in patients with stable HF, but its impact is less clear in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to analyze the effects of the exercise training on cardiovascular outcomes in patients with HFpEF. A systematic literature search was conducted on the main electronic databases, proceedings of major meetings, and reference lists of the identified studies, using specific terms for only English language studies published between 2000 and 2018. We followed the PRISMA to perform our review. Quality of studies was also assessed. The systematic review identified 9 studies on 348 patients, of moderate (n = 2) to good (n = 7) quality. The training consisted of a combination of supervised in-hospital and home-based outpatient programs, including aerobic exercise, endurance and resistance training, walking, and treadmill and bicycle ergometer. Most of the protocols ranged 12-16 weeks, with a frequency of 2-3 sessions weekly, lasting 20-60 min per session. There were significant improvements in peak oxygen uptake, 6-min walking test distance, and ventilatory threshold, whereas quality of life and echocardiographic parameters improved only in some studies. Endothelial function/arterial stiffness remained unchanged. No adverse events were reported. Appropriate exercise programs are able to get a favorable cardiovascular outcome in patients with HFpEF. This could also benefit in terms of quality of life, even if more controversial. Further researches are necessary.

Indexed as

Quality of LifeEchocardiographyExercise TherapyExercise ToleranceHeart FailureHumansStroke VolumeVascular StiffnessVentricular Function, LeftHeart failureHeart failure with preserved ejection fractionPersonalized medicinePhysical activityRehabilitation

Identifiers

PMID31399956
OpenAlexW2967347511

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.