Evidence map›Paper›PMID 31404299›Full record

SynthesisFrontiers in psychiatry2019

Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

Mingyu Xu, Xuefeng Xu, Jijun Li, Fei Li

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06290258 (Fecal Microbiota Transplantation for Gastrointestinal, Autistic, Emotion, and Behavior Symptoms of Patients With Autism Spectrum Disorder and Gastrointestinal Problems), which is not on this map. Cited by 163 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 8 pooled it
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06290258 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Fecal Microbiota Transplantation for Gastrointestinal, Autistic, Emotion, and Behavior Symptoms of Patients With Autism Spectrum Disorder and Gastrointestinal Problems: a Preliminary Study.

TypeinterventionalSponsorChang Gung Memorial HospitalRan2024 to 2027Enrolled60ConditionsAutism Spectrum Disorder, Gastrointestinal Diseases, HealthyArmsFecal microbiota transplantation
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 8 syntheses or guidelines pooled it, 299 citations in OpenAlex.

  1. Pooled it
  2. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  3. A Meta-analysis of Gut Microbiota in Children with Autism.Journal of autism and developmental disorders · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026
    Review
  19. Review
  20. Review

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mingyu XuDevelopmental and Behavioral Pediatric & Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuefeng XuDepartment of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jijun LiDepartment of Integrative Medicine on Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fei LiDevelopmental and Behavioral Pediatric & Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNChildren's Hospital of Zhejiang University · CNShanghai Children's Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is characterized by stereotyped behavior and deficits in communication and social interactions. Gastrointestinal (GI) dysfunction is an ASD-associated comorbidity, implying a potential role of the gut microbiota in ASD GI pathophysiology. Several recent studies found that autistic individuals harbor an altered bacterial gut microbiota. In some cases, remodeling the gut microbiota by antibiotic administration and microbiota transfer therapy reportedly alleviated the symptoms of ASD. However, there is little consensus on specific bacterial species that are similarly altered across individual studies. The aim of this study is to summarize previously published data and analyze the alteration of the relative abundance of bacterial genera in the gut microbiota in controls and individuals with ASD using meta-analysis. We analyzed nine studies, including 254 patients with ASD, and found that children with ASD had lower percentages of

Indexed as

autism spectrum disorderchildrenGI problemsgut microbiotameta-analysismicroflora

Identifiers

PMID31404299
PMCPMC6673757
OpenAlexW2952173081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.