ArticleDiabetology & metabolic syndrome2019
Myokine-adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome.
Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Circulating irisin levels in patients with MAFLD: an updated systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis.BMC pediatrics · 2022Pooled it
- Effect of exercise on hormonal responses in adolescents with obesity and leptin resistance: a randomized trial.Scientific reports · 2026Trial
- Optimal exercise modalities and dose selection to reduce leptin levels in overweight or obese individuals: a network meta-analysis and dose-response relationship study.BMC sports science, medicine & rehabilitation · 2025Article
- Association between lean mass and the risk of metabolic syndrome in Korean children and adolescents: data from the Korea National Health and Nutrition Examination survey.Endocrine journal · 2025Article
- Alterations in Adipokine Levels Are Associated with Human Perinatal Anxiety and Depression.Journal of clinical medicine · 2025Article
- Article
- Influence of Sex and Age on Irisin Levels in Pediatric Type 1 Diabetes: A Pilot Study.Journal of clinical medicine · 2025Article
- Article
- Complete Blood Count-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Children and Adolescents with Severe Obesity.Journal of clinical medicine · 2024Article
- Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children.Medicina (Kaunas, Lithuania) · 2023Article
- Criteria in the Diagnosis of Metabolic Syndrome in Children: A Scoping Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- Leptin signaling and leptin resistance.Medical review (2021) · 2022Review
- Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19.European journal of applied physiology · 2020Review
- Obesity Risk Assessment Tool for Low-Income Spanish Speaking Immigrant Parents with Young Children: Validity with BMI and Biomarkers of Obesity.Nutrients · 2020Article
- Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications.International journal of molecular sciences · 2020Review
- Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis.Nutrients · 2020Review
- Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome.Journal of diabetes research · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipokines and the myokine irisin, involved in mechanisms associated with obesity and metabolic syndrome (MS), are understudied in the pediatric population.
objectiveTo investigate the relationship between irisin, and leptin, resistin, adiponectin, adipsin, anthropometric and cardiovascular risk factors in Mexican children.
methodsA cross-sample of 126 Mexican children aged 6-12 years old were classified as normal weight (n = 46), obese (n = 40), and MS (n = 40) according to CDC's and Cook's age-modified criteria for obesity and MS. Anthropometric parameters and blood pressure were determined and percentiles calculated for age and gender. Irisin, leptin, adiponectin, adipsin, resistin, triglycerides, glucose, high-density lipoprotein cholesterol (HDL-c) levels, and physical activity were determined. Statistical tests for differences between groups, correlation, and multiple regression analyses were performed.
resultsIrisin plasma levels were significantly lower in the obese (6.08 [4.68-6.65]) and MS groups (6.46 [5.74-7.02]) compared with the normal-weight group (8.05 [7.24-8.94]) (p < 0.001). Irisin levels were not influenced by age or gender, but significant dispersion was observed in obese girls (95% CI median [2.29-6.30]). Leptin, resistin, and adipsin levels were significantly increased in the obese and MS groups. Lean-fat ratio was significantly higher in the NW group. Irisin correlated negatively with leptin (- 0.310), resistin (- 0.389), adipsin (- 0.362), BMI% (-0.472), WC% (- 0.453), BMI z-score (- 0.496), fat free mass (- 0.257), fat percentage (- 0.532), fat mass (- 0.515), triglycerides (- 0.291), the number of cardiometabolic risk factors (- 0.443) (p < 0.001); positively with lean-fat ratio (0.489) and HDL-c (0.328) (p < 0.001) and none with physical activity (
conclusionsLean-fat ratio, more than the absolute amount of muscle or fat mass, as well as potential myokine-adipokine cross-talk mechanisms may explain the lower irisin levels in children with obesity and MS, through blunted compensatory responses interfering with tissue-dependent irisin secretion, contributing to a continuous deleterious effect cycle.
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