Evidence map›Paper›PMID 31405104›Full record

ArticleInternational journal of molecular sciences2019

Effect of Ionizing Radiation from Computed Tomography on Differentiation of Human Embryonic Stem Cells into Neural Precursors.

Christine Hanu, Burk W Loeliger, Irina V Panyutin, Roberto Maass-Moreno, Paul Wakim, William F Pritchard, Ronald D Neumann, Igor G Panyutin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christine HanuDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Burk W LoeligerDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Irina V PanyutinDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Roberto Maass-MorenoDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Paul WakimBiostatistics and Clinical Epidemiology Service, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.ORCID 0000-0002-5951-0983
William F PritchardDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Ronald D NeumannDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA.
Igor G PanyutinDepartment of Radiology and Imaging Sciences, Clinical Center, NIH, 10 Center Dr., Bethesda, MD 20892, USA. ipanyuting@mail.nih.gov.
National Institutes of Health Clinical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of radiation from computed tomography (CT) scans on differentiation of human embryonic stem cells (hESCs) into neuronal lineage. hESCs were divided into three radiation exposure groups: 0-dose, low-dose, or high-dose exposure. Low dose was accomplished with a single 15 mGy CT dose index (CTDI) CT scan that approximated the dose for abdominal/pelvic CT examinations in adults while the high dose was achieved with several consecutive CT scans yielding a cumulative dose of 500 mGy CTDI. The neural induction was characterized by immunocytochemistry. Quantitative polymerase chain reaction (qPCR) and Western blots were used to measure expression of the neuronal markers

Indexed as

Cell LineDown-RegulationHuman Embryonic Stem CellsHumansNeural Stem CellsNeurogenesisPAX6 Transcription FactorRadiation DosageRadiation, IonizingTomography, X-Ray ComputedPAX6 protein, humanPAX6 Transcription Factorcomputed tomographyhuman embryonic stem cell differentiationlow-dose radiationnestinPAX6

Identifiers

PMID31405104
PMCPMC6720494
OpenAlexW2967490671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.