Evidence map›Paper›PMID 31406157›Full record

ArticleScientific reports2019

Targeted sequencing of linkage region in Dominican families implicates PRIMA1 and the SPATA7-PTPN21-ZC3H14-EML5-TTC8 locus in carotid-intima media thickness and atherosclerotic events.

Liyong Wang, Nicole Dueker, Ashley Beecham, Susan H Blanton, Ralph L Sacco, Tatjana Rundek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Hypermethylation ofJournal of the American Heart Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liyong WangJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA. lwang1@miami.edu.ORCID http://orcid.org/0000-0001-8299-2602
Nicole DuekerJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ashley BeechamJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Susan H BlantonJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ralph L SaccoJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Tatjana RundekJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
University of Miami · US

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
FAMILY STUDY OF STROKE RISK AND CAROTID ATHEROSCLEROSISR01NS040807 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLANTON, SUSAN HALLORAN, RUNDEK, TATJANA · 2002 to 2022
$12.2M
NINDS NIH HHS R01 NS040807U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R0129993
6 · The paper itself

Abstract

Carotid intima-media thickness (cIMT) is a subclinical marker for atherosclerosis. Previously, we reported a quantitative trait locus (QTL) for total cIMT on chromosome 14q and identified PRiMA1, FOXN3 and CCDC88C as candidate genes using a common variants (CVs)-based approach. Herein, we further evaluated the genetic contribution of the QTL to cIMT by resequencing. We sequenced all exons within the QTL and genomic regions of PRiMA1, FOXN3 and CCDC88C in Dominican families with evidence for linkage to the QTL. Unrelated Dominicans from the Northern Manhattan Study (NOMAS) were used for validation. Single-variant-based and gene-based analyses were performed for CVs and rare variants (RVs). The strongest evidence for association with CVs was found in PRiMA1 (p = 8.2 × 10

Indexed as

Carotid Intima-Media ThicknessGenetic LinkageAtherosclerosisCytoskeletal ProteinsDNA-Binding ProteinsDominican RepublicFemaleHumansLod ScoreMaleMembrane ProteinsMicrotubule-Associated ProteinsNerve Tissue ProteinsPoly(A)-Binding ProteinsPolymorphism, Single NucleotideProtein Tyrosine Phosphatases, Non-ReceptorCytoskeletal ProteinsDNA-Binding ProteinsMembrane ProteinsMicrotubule-Associated ProteinsNerve Tissue ProteinsPoly(A)-Binding ProteinsPRIMA1 protein, humanProtein Tyrosine Phosphatases, Non-ReceptorPTPN21 protein, humanSPATA7 protein, humanTTC8 protein, humanZC3H14 protein, human

Identifiers

PMID31406157
PMCPMC6691113
OpenAlexW2969051753

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.