Evidence map›Paper›PMID 31407456›Full record

ReviewNeurogastroenterology and motility2020

Childhood gastroparesis is a unique entity in need of further investigation.

Liz Febo-Rodriguez, Bruno P Chumpitazi, Robert J Shulman

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Neurogastroenterology and motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05981300 (GpCRC Pediatric Gastroparesis Registry 2), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05981300 recruitingnot on this mapstarted 2024, after this paper: background citation

GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis

Typeobservational_patient_registrySponsorJohns Hopkins Bloomberg School of Public HealthRan2024 to 2027Enrolled216ConditionsGastroparesis, Gastroparesis-like Syndrome
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Dietary Interventions for Gastroparesis: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2022
    Pooled it
  3. Trial
  4. Review
  5. Article
  6. Evaluating the Efficacy and Safety of Erythromycin for the Treatment of Gastroparesis in Infants and Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Liz Febo-RodriguezDepartment of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0001-8362-8781
Bruno P ChumpitaziDepartment of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-0829-0036
Robert J ShulmanDepartment of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0003-2385-0991
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Advancing Clinical Science in Pediatric GastroparesisU01DK112194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Bruno Pedro Chumpitazi, Geoffrey A Preidis · 2016 to 2026
$5.3M
DO BIOMARKERS PREDICT RESPONSE TO A PEDIATRIC CHRONIC PAIN SYMPTOM MANAGEMENT PROGRAM?R01NR016786 · NINR · BAYLOR COLLEGE OF MEDICINE · PI LEVY, RONA L., SHULMAN, ROBERT J · 2018 to 2023
$2.9M
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBSK23DK101688 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHUMPITAZI, BRUNO PEDRO · 2014 to 2018
$879k
Nonbacterial Gut Microbiome and Fructan Symptom Generation in Childhood IBSR03DK117219 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHUMPITAZI, BRUNO PEDRO · 2018 to 2019
$238k
NIDDK NIH HHS K23 DK101688NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R03 DK117219NIDDK NIH HHS U01 DK112194NINR NIH HHS R01 NR016786
6 · The paper itself

Abstract

backgroundDespite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP-specific pediatric reported outcome measures. PURPOSE: The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co-morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric-focused therapies.

Indexed as

GastroparesisChildFemaleHumansMalegastric emptyinggastroparesismotilitypediatric gastroenterology

Identifiers

PMID31407456
PMCPMC7015769
OpenAlexW2967221052

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.