ArticleScientific reports2019
Serum and brain natural copper stable isotopes in a mouse model of Alzheimer's disease.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Toward diagnostically relevant isotope-ratio biomarkers: what does MC-ICP-MS still need for standardized measurements?Analytical and bioanalytical chemistry · 2026Review
- Advancing Stable Isotope Analysis with Orbitrap-MS for Fatty Acid Methyl Esters and Complex Lipid Matrices.Journal of the American Society for Mass Spectrometry · 2025Article
- Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease.Metallomics : integrated biometal science · 2024Article
- Impact of aging on copper isotopic composition in the murine brain.Metallomics : integrated biometal science · 2024Article
- Metal-binding amino acid ligands commonly found in metalloproteins differentially fractionate copper isotopes.Scientific reports · 2024Article
- Full-Stokes polarization laser-induced breakdown spectroscopy detection of infiltrative glioma boundary tissue.Biomedical optics express · 2023Article
- Alzheimer's Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APPBiology · 2023Article
- Contribution of Ryugu-like material to Earth's volatile inventory by Cu and Zn isotopic analysis.Nature astronomy · 2022Article
- Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease.Metallomics : integrated biometal science · 2022Article
- Magnesium stable isotope composition, but not concentration, responds to obesity and early insulin-resistant conditions in minipig.Scientific reports · 2022Article
- A novel dual-emission fluorescent probe for ratiometric and visual detection of CuAnalytical and bioanalytical chemistry · 2022Article
- High-Precision Isotopic Analysis of Cu and FeFrontiers in chemistry · 2022Article
- Biogenic metallic elements in the human brain?Science advances · 2021Article
- Iron Isotopic Composition of Biological Standards Relevant to Medical and Biological Applications.Frontiers in medicine · 2021Article
- Metals in Imaging of Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Isotope metallomics approaches for medical research.Cellular and molecular life sciences : CMLS · 2020Review
- Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Copper isotope shifts in biofluids track Alzheimer's pathology.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.The Journal of biological chemistryArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease is associated with the production of Cu rich aβ fibrils. Because monitoring the changes in Cu level of organs has been proposed to follow the evolution of the disease, we analyzed the copper isotopic composition of serum and brain of APPswe/PSEN1dE9 transgenic mice, a model of Alzheimer's disease, and wild-type (WT) controls. Serum composition of 3, 6, 9 and 12-month-old mice, as well as the composition of 9 brains of 12-month-old mice are reported. In WT mice, brains were ~1‰ isotopically heavier than serum, and the Cu isotopic composition of the serum was isotopically different between males and females. We propose that this effect of sex on the Cu isotopic budget of the serum may be related to a difference of Cu speciation and relative abundance of Cu carriers. Brains of APPswe/PSEN1dE9 mice were slightly lighter than brains of WT mice, while not statistically significant. This trend may reflect an increase of Cu(I) associated with the formation of Aβ fibrils. The Cu isotopic composition of the brains and serum were correlated, implying copper transport between these two reservoirs, in particular a transfer of Cu(I) from the brain to the serum. Altogether, these data suggest that Cu stable isotopic composition of body fluid may have the potential to be used as detection tools for the formation of Aβ fibrils in the brain, but further work has to be done.
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