ArticleJournal of experimental botany2019
GABA operates upstream of H+-ATPase and improves salinity tolerance in Arabidopsis by enabling cytosolic K+ retention and Na+ exclusion.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 130 citations in OpenAlex.
- A laser capture microdissection-based transcriptome analysis on salt glands highlights salt secretion mechanism in mangrove plant Avicennia marina.The Plant journal : for cell and molecular biology · 2026Article
- Minimally invasive quantitative tracking of minerals, sugars, amino acids, and hormones in the leaf apoplast of Arabidopsis thaliana and Vicia faba.Journal of experimental botany · 2026Article
- Genome-Wide Identification of the WheatPlants (Basel, Switzerland) · 2026Article
- GABA-mediated regulation of lipid metabolism: a conserved relation with diverse physiological significances.Frontiers in physiology · 2026Review
- Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress.Plants (Basel, Switzerland) · 2026Review
- Integrated physiological and multi-omics analyses reveal genotype-specific GABA responses associated with salt tolerance inFrontiers in plant science · 2026Article
- PagSAMDC4a-Mediated Polyamine Synthesis Regulate Vessel Differentiation Under Drought Stress Conditions in Poplar.Plant biotechnology journal · 2025Article
- Patch-Clamp- andPlant, cell & environment · 2025Article
- Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality.Plants (Basel, Switzerland) · 2025Review
- Application of γ-aminobutyric acid alleviates salinity-mediated growth decline and oxidative damage by increasing proline and antioxidant functioning in olive (Frontiers in plant science · 2025Article
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- GABA promotes peroxisome proliferation inPlant direct · 2024Article
- Endogenous γ-Aminobutyric Acid Accumulation Enhances Salinity Tolerance in Rice.Plants (Basel, Switzerland) · 2024Article
- MdSINA2-MdNAC104 Module Regulates Apple Alkaline Resistance by Affecting γ-Aminobutyric Acid Synthesis and Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Gamma-aminobutyric acid interactions with phytohormones and its role in modulating abiotic and biotic stress in plants.Stress biology · 2024Review
- Gamma-aminobutyric acid (GABA) improves salinity stress tolerance in soybean seedlings by modulating their mineral nutrition, osmolyte contents, and ascorbate-glutathione cycle.BMC plant biology · 2024Article
- Exogenous application of salicylic acid ameliorates salinity stress in barley (Hordeum vulgare L.).BMC plant biology · 2024Article
- Truncation of the calmodulin binding domain in rice glutamate decarboxylase 4 (Molecular breeding : new strategies in plant improvement · 2024Article
- GABA: a key player of abiotic stress regulation.Plant signaling & behavior · 2023Article
- Exogenous γ-Aminobutyric Acid Can Improve Seed Germination and Seedling Growth of Two Cotton Cultivars under Salt Stress.Plants (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The non-protein amino acid γ-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to salinity. However, the physiological rationale for this elevation remains elusive. This study compared electrophysiological and whole-plant responses of salt-treated Arabidopsis mutants pop2-5 and gad1,2, which have different abilities to accumulate GABA. The pop2-5 mutant, which was able to overaccumulate GABA in its roots, showed a salt-tolerant phenotype. On the contrary, the gad1,2 mutant, lacking the ability to convert glutamate to GABA, showed oversensitivity to salinity. The greater salinity tolerance of the pop2-5 line was explained by: (i) the role of GABA in stress-induced activation of H+-ATPase, thus leading to better membrane potential maintenance and reduced stress-induced K+ leak from roots; (ii) reduced rates of net Na+ uptake; (iii) higher expression of SOS1 and NHX1 genes in the leaves, which contributed to reducing Na+ concentration in the cytoplasm by excluding Na+ to apoplast and sequestering Na+ in the vacuoles; (iv) a lower rate of H2O2 production and reduced reactive oxygen species-inducible K+ efflux from root epidermis; and (v) better K+ retention in the shoot associated with the lower expression level of GORK channels in plant leaves.
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