Evidence map›Paper›PMID 31422694›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Smooth Muscle Cell-Specific Disruption of the BBSome Causes Vascular Dysfunction.

John J Reho, Deng-Fu Guo, Donald A Morgan, Kamal Rahmouni

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Vascular Mechanobiology: From Membrane to Nucleus.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Adipocyte-specific disruption of the BBSome causes metabolic and autonomic dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Cardiovascular Regulation by the Neuronal BBSome.Hypertension (Dallas, Tex. : 1979) · 2020
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

John J RehoFrom the Department of Pharmacology (J.J.R., D.-F.G., D.A.M., K.R.), University of Iowa Carver College of Medicine.
Deng-Fu GuoFrom the Department of Pharmacology (J.J.R., D.-F.G., D.A.M., K.R.), University of Iowa Carver College of Medicine.
Donald A MorganFrom the Department of Pharmacology (J.J.R., D.-F.G., D.A.M., K.R.), University of Iowa Carver College of Medicine.
Kamal RahmouniFrom the Department of Pharmacology (J.J.R., D.-F.G., D.A.M., K.R.), University of Iowa Carver College of Medicine.
University of Iowa · USFraternal Order of Eagles · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Neuronal Mechanisms of Obesity-Induced HypertensionI01BX004249 · VA · IOWA CITY VA MEDICAL CENTER · PI KAMAL RAHMOUNI · 2019 to 2026
–
BLRD VA I01 BX004249NHLBI NIH HHS P01 HL084207
6 · The paper itself

Abstract

The BBSome-a complex consisting of 8 Bardet-Biedl syndrome proteins-is involved in the regulation of various cellular processes. Recently, the BBSome complex has emerged as an important regulator of cardiovascular function with implications for disease. In this study, we examined the role of the BBSome in vascular smooth muscle and its effects on the regulation of cardiovascular function. Smooth muscle-specific disruption of the BBSome through tamoxifen-inducible deletion of

Indexed as

AngiotensinogenAnimalsAortaBlood PressureMesenteric ArteriesMiceMice, TransgenicMicrotubule-Associated ProteinsMuscle, Smooth, VascularMyocytes, Smooth MuscleVascular StiffnessVasodilationAngiotensinogenBbs1 protein, mouseMicrotubule-Associated Proteinsanimalsciliamicemuscle, smoothrenin-angiotensin system

Identifiers

PMID31422694
PMCPMC6739154
OpenAlexW2969719577

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.