SynthesisJournal of the American Heart Association2019
Genome-Wide Meta-Analysis of Blood Pressure Response to β
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies.Clinical pharmacology and therapeutics · 2021Pooled it
- Genome-Wide Meta-Analysis of Blood Pressure Response to βJournal of the American Heart Association · 2019Pooled it
- Trial
- SLC16A1 lactylation links epimetabolic reprogramming of triglycerides (50:3 and 50:1) to blood pressure regulation.SAGE open medicine · 2026Article
- Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study.Journal of translational medicine · 2025Article
- Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.Nature communications · 2025Article
- Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization.European stroke journal · 2024Article
- Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.medRxiv : the preprint server for health sciences · 2024Article
- Article
- miR-4432 Targets FGFBP1 in Human Endothelial Cells.Biology · 2023Article
- Therapeutic Properties of Highly Selective β-blockers With or Without Additional Vasodilator Properties: Focus on Bisoprolol and Nebivolol in Patients With Cardiovascular Disease.Cardiovascular drugs and therapy · 2022Review
- Genetically predicted on-statin LDL response is associated with higher intracerebral haemorrhage risk.Brain : a journal of neurology · 2022Article
- Pharmacogenomics Informs Cardiovascular Pharmacotherapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol.Pharmacogenomics and personalized medicine · 2022Article
- Pharmacogenomic Effects of β-Blocker Use on Femoral Neck Bone Mineral Density.Journal of the Endocrine Society · 2021Article
- Pharmacogenomics in Cardiovascular Diseases.Current protocols · 2021Article
- Article
- Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses.Scientific reports · 2020Article
- Association of West African ancestry and blood pressure control among African Americans taking antihypertensive medication in the Jackson Heart Study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Pharmacogenomics And Hypertension: Current Insights.Pharmacogenomics and personalized medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 11 institutions in 4 countries.
Sonal SinghDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
Helen R WarrenWilliam Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London United Kingdom.
Timo P HiltunenDepartment of Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland.
Caitrin W McDonoughDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
Nihal El RoubyDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
Erika SalviNeuroalgology Unit Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan Italy.
Zhiying WangHuman Genetics and Institute of Molecular Medicine University of Texas Health Science Center Houston TX.
Tatiana GarofalidouWilliam Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London United Kingdom.
Frej FyhrquistMinerva Foundation Institute for Medical Research Helsinki Finland.
Kimmo K KontulaDepartment of Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland.
Valeria GloriosoFaculty of Biostatistics University of Milano Bicocca Italy.
Roberta ZaninelloHypertension and related diseases Centre Department of Clinical and Experimental Medicine University of Sassari Italy.
Nicola GloriosoHypertension and related diseases Centre Department of Clinical and Experimental Medicine University of Sassari Italy.
Carl J PepineDivision of Cardiovascular Medicine Department of Medicine University of Florida Gainesville FL.
Patricia B MunroeWilliam Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London United Kingdom.
Stephan T TurnerDivision of Nephrology and Hypertension Mayo Clinic Rochester MN.
Arlene B ChapmanDivision of Nephrology University of Chicago IL.
Eric BoerwinkleHuman Genetics and Institute of Molecular Medicine University of Texas Health Science Center Houston TX.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine University of Florida Gainesville FL.
University of Florida · USHelsinki University Hospital · FIQueen Mary University of London · GBThe University of Texas Health Science Center at Houston · USUniversity of Sassari · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITMayo Clinic · USMinerva Foundation · FINational Institute for Health Research · GBUniversity of Illinois Chicago · USUniversity of Milano-Bicocca · IT
Funding
Phenotyping--vasoactive post synaptic agonist pharmacogU01HL069758 · UNIVERSITY OF CALIFORNIA SAN DIEGO · 2001 to 2004
$12.1MHypertension PharmacogeneticsR01HL074730 · UNIVERSITY OF FLORIDA · 2003 to 2005
$2.6MPharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · UNIVERSITY OF FLORIDA · 2005 to 2005
$1.6MEXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR017568 · UNIVERSITY OF FLORIDA · 2003 to 2003
$900kNCATS NIH HHS KL2 TR001429NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR000454NCRR NIH HHS C06 RR017568NHLBI NIH HHS K01 HL141690NHLBI NIH HHS R01 HL074730NHLBI NIH HHS U01 HL069758NIGMS NIH HHS U01 GM074492
Abstract
BackgroundThere exists a wide interindividual variability in blood pressure (BP) response to β
Indexed as
Blood PressurePharmacogenomic VariantsADP-ribosyl CyclaseAdrenergic beta-1 Receptor AntagonistsAntigens, CDAtenololBisoprololBlack PeopleGenome-Wide Association StudyGPI-Linked ProteinsHumansHypertensionMetoprololMutation, MissensePharmacogeneticsPolymorphism, Single NucleotideADP-ribosyl CyclaseADP-ribosyl cyclase 2Adrenergic beta-1 Receptor AntagonistsAntigens, CDAtenololBisoprololGPI-Linked ProteinsMetoprololblood pressurehypertensionmeta‐analysispharmacogenomicsβ1‐blockerβ‐blocker
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.