Evidence map›Paper›PMID 31426749›Full record

Trial reportBMC cardiovascular disorders2019

Effects of ezetimibe/simvastatin 10/10 mg versus Rosuvastatin 10 mg on carotid atherosclerotic plaque inflammation.

Minyoung Oh, Hyunji Kim, Eon Woo Shin, Changhwan Sung, Do-Hoon Kim, Dae Hyuk Moon, Cheol Whan Lee

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02378064 (Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation), which is not on this map. Cited by 7 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02378064 phase4completednot on this map

Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation

TypeinterventionalSponsorCHEOL WHAN LEE, M.D., Ph.DRan2015 to 2017Enrolled50ConditionsInflammation Plaque, Atherosclerotic, Coronary Disease, Renin-Angiotensin SystemArms6-month treatment
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Minyoung OhDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Hyunji KimDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Eon Woo ShinDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Changhwan SungDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Do-Hoon KimDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Dae Hyuk MoonDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Cheol Whan LeeDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. cheolwlee@amc.seoul.kr.ORCID 0000-0003-3987-2159
Ulsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUsing

methodsIn this 2-by-2 factorial trial, 50 patients with

resultsBaseline characteristics of the two groups were largely similar. At 6-month follow-up, the MDS TBR of the index vessel and aorta significantly decreased in ezetimibe/simvastatin group and tended to decrease in rosuvastatin group. However, the percent change in the MDS TBR of the index vessel was similar between the 2 groups (- 10.22 ± 17.49% vs. -5.84 ± 15.78%, respectively, p = 0.357), as was the percent change in the whole vessel TBR of the index vessel. Likewise, the changes in the MDS TBR or whole vessel TBR of the aorta were similar in both groups. Total cholesterol and low-density lipoprotein cholesterol levels improved to a similar degree in both groups.

conclusionTreatment with ezetimibe/simvastatin versus rosuvastatin resulted in a similar improvement of carotid atherosclerotic plaque inflammation, suggesting their equivalent anti-inflammatory effects.

trial registrationThe trial is registered at ClinicalTrials.gov : NCT02378064, 3-4-2015. /IRB No. 2015-0194.

Indexed as

Plaque, AtheroscleroticAgedAnti-Inflammatory AgentsCarotid Artery DiseasesEzetimibe, Simvastatin Drug CombinationFemaleFluorodeoxyglucose F18HumansHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationMaleMiddle AgedPositron Emission Tomography Computed TomographyPredictive Value of TestsRadiopharmaceuticalsRosuvastatin CalciumAnti-Inflammatory AgentsEzetimibe, Simvastatin Drug CombinationFluorodeoxyglucose F18Hydroxymethylglutaryl-CoA Reductase InhibitorsRadiopharmaceuticalsRosuvastatin CalciumEzetimibePlaque inflammationPositron emission tomographyStatin

Identifiers

PMID31426749
PMCPMC6700958
OpenAlexW2969770771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.