SynthesisOxidative medicine and cellular longevity2019
Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis.
Synthesis in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.Nutrients · 2023Pooled it
- Adjunctive subgingival application of Chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis.BMC oral health · 2020Pooled it
- Use of over-the-counter mouthwashes as an additional measure in individual oral prophylaxis on adults with plaque-induced gingivitis: a double-blind, parallel, randomized controlled trial.BMC oral health · 2024Trial
- Efficacy of antioxidants supplementation as an adjunct to non-surgical periodontal therapy: an umbrella meta-analysis.Odontology · 2026Review
- Protective Effects of Mixed Probiotics, Oralis SBAntioxidants (Basel, Switzerland) · 2026Article
- N-Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis.International endodontic journal · 2026Article
- Effects of Nutritional Supplements Alone or as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis.International journal of dentistry · 2026Review
- Effects of Zanthoxyli Pericarpium Extracts on Ligature-Induced Periodontitis and Alveolar Bone Loss in Rats.Antioxidants (Basel, Switzerland) · 2025Article
- The effect of systemic lycopene supplementation on non-surgical periodontal therapy outcomes: A clinical trial.BDJ open · 2025Article
- Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice.The journal of physiological sciences : JPS · 2025Article
- Association between composite dietary antioxidant index and the prevalence of periodontitis: results from NHANES 2009-2014.BMC oral health · 2025Article
- Effect of yogic breathing (pranayama) on periodontal health status, salivary oxidative stress, and antioxidant levels in adults aged 35 to 44 in India: a cross-sectional study.European journal of medical research · 2025Article
- DNA Methylation in Periodontal Disease: A Focus on Folate, Folic Acid, Mitochondria, and Dietary Intervention.International journal of molecular sciences · 2025Review
- The relationship of stress level and periodontal tissue health in soldiers from Kodam Jaya: a cross-sectional study.Frontiers in oral health · 2025Article
- Guardians of Oral Health: Antioxidants as Promising Allies in Periodontal Wellness.Journal of pharmacy & bioallied sciences · 2024Review
- Insights into the antioxidant, anti-inflammatory and anti-microbial potential of Nigella sativa essential oil against oral pathogens.Scientific reports · 2024Article
- The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases.Biomedicines · 2024Article
- Article
- The Potential Uses of Baobab Tree's Medicinal Effects in Dentistry: A Literature Review.Cureus · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review with meta-analysis aimed to evaluate the effect of antioxidants as an adjuvant in periodontitis treatment. The following databases were consulted: PubMed, Scopus, Web of Science, Cochrane, Lilacs, OpenGrey, and Google Scholar. Based on the PICO strategy, the inclusion criteria comprised interventional studies including periodontitis patients (participants) treated with conventional therapy and antioxidants (intervention) compared to patients treated only with conventional therapy (control) where the periodontal response (outcome) was evaluated. The risk of bias was evaluated using the Cochrane RoB tool (for randomized studies) and ROBINS-I tool (for nonrandomized studies). Quantitative data were analyzed in five random effects meta-analyses considering the following periodontal parameters: clinical attachment loss (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and probing depth (PD). After all, the level of certainty was measured with the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool. Among the 1884 studies identified, only 15 interventional studies were according to the eligibility criteria and they were included in our review. From them, 4 articles presented a high risk of bias. The meta-analysis showed a statistically significant difference for CAL (SMD 0.29 (0.04, 0.55),
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.