Evidence map›Paper›PMID 31429102›Full record

ArticleJournal of applied toxicology : JAT2019

Antimicrobial agent triclosan suppresses mast cell signaling via phospholipase D inhibition.

Juyoung K Shim, Molly A Caron, Lisa M Weatherly, Logan B Gerchman, Suraj Sangroula, Siham Hattab, Alan Y Baez, Talya J Briana, Julie A Gosse

Open access · greenAbstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Triclosan disrupts immune cell function by depressing CaToxicology and applied pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Juyoung K ShimDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Molly A CaronDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Lisa M WeatherlyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Logan B GerchmanDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Suraj SangroulaDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Siham HattabDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Alan Y BaezDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Talya J BrianaDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.
Julie A GosseDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine.ORCID 0000-0002-2457-4039
University of Maine · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Mechanism of Triclosan Disruption of Mast Cell FunctionR15ES024593 · NIEHS · UNIVERSITY OF MAINE ORONO · PI GOSSE, JULIE ANN · 2014 to 2014
$421k
Michael J. Eckardt Dissertation Fellowship (University of Maine)NIEHS NIH HHS R15 ES024593NIEHS NIH HHS R15ES24593NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20GM103423Radke Research Fellowship (University of Maine)
6 · The paper itself

Abstract

Humans are exposed to the antimicrobial agent triclosan (TCS) through use of TCS-containing products. Exposed tissues contain mast cells, which are involved in numerous biological functions and diseases by secreting various chemical mediators through a process termed degranulation. We previously demonstrated that TCS inhibits both Ca

Indexed as

Anti-Infective AgentsCalciumCell DegranulationCell LineHumansMast CellsMyristoylated Alanine-Rich C Kinase SubstratePhospholipase DProtein Kinase CReactive Oxygen SpeciesSignal TransductionTriclosanAnti-Infective AgentsCalciumMARCKS protein, humanMyristoylated Alanine-Rich C Kinase SubstratePhospholipase DProtein Kinase CReactive Oxygen SpeciesTriclosancalciumdegranulationmast cellphospholipase Dprotein kinase Ctriclosan

Identifiers

PMID31429102
PMCPMC6861621
OpenAlexW2969709322

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.