Evidence map›Paper›PMID 31430566›Full record

SynthesisAgeing research reviews2019

Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies.

Mei Xue, Wei Xu, Ya-Nan Ou, Xi-Peng Cao, Meng-Shan Tan, Lan Tan, Jin-Tai Yu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Ageing research reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05262257 (Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.), which is not on this map. Cited by 376 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 11 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05262257 early_phase1unknown statusstarted 2022, after this paper: background citation

Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.

Ran2022Enrolled120Registered outcomes4Posted comparisons0ConditionsType2 DiabetesArmsdapagliflozin, Lifestyle Intervention, Metformin
PMID 29368156PMID 29626315PMID 30866531PMID 32848437PMID 32941881PMID 33187206PMID 34234493PMID 34291435PMID 26969101PMID 25698435PMID 25344694PMID 24622756other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 11 syntheses or guidelines pooled it, 673 citations in OpenAlex.

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  4. Merits of bioactivity and products ofFrontiers in plant science · 2026
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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mei XueDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Ya-Nan OuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Xi-Peng CaoClinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Meng-Shan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Jin-Tai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: jintai_yu@fudan.edu.cn.
Qingdao University · CNQingdao Municipal Hospital · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUncertainties persist about the associations of diabetes with risk of cognitive impairment and dementia. We aimed to illuminate these associations from various aspects.

methodsWe identified relevant prospective studies by searching PubMed up to Jun 2019. Summary relative risks (RR) were estimated using random-effects models. Credibility of each meta-analysis was assessed. Meta-regression and subgroup analyses were conducted.

resultsOf 28,082 identified literatures, 144 were eligible for inclusion in the systematic review, among which 122 were included in the meta-analysis. Diabetes conferred a 1.25- to 1.91-fold excess risk for cognitive disorders (cognitive impairment and dementia). Subjects with prediabetes also had higher risk for dementia. As for diabetes-related biochemical indicators, fasting plasma glucose (FPG) was non-linearly related to cognitive disorders; the elevated levels of 2 -h postload glucose (2h-PG), glycosylated hemoglobin (HbA1c), low and high levels of fasting plasma insulin (FPI) were associated with an increased risk of dementia. Encouragingly, the use of pioglitazone exhibited a 47% reduced risk of dementia in diabetic population.

conclusionsDiabetes, even prediabetes and changes of diabetes-related biochemical indicators, predicted increased incidence of cognitive impairment and dementia. The protective effects of pioglitazone warrant further investigation in randomized trials.

Indexed as

Diabetes ComplicationsCognitive DysfunctionDementiaFemaleHumansMaleCognitive impairmentDementiaDiabetesGlucoseInsulinMeta-Analysis

Identifiers

PMID31430566
OpenAlexW2966966909

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.