ArticleJournal of cachexia, sarcopenia and muscle2020
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.
Article in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Structural and Metabolic Remodeling of Skeletal Muscle in Heart Failure with Reduced Ejection Fraction: A Review: Beyond the Failing Heart.International journal of molecular sciences · 2026Review
- Skeletal muscle transcriptional dysregulation of genes involved in senescence is associated with prognosis in severe heart failure.Communications medicine · 2026Article
- Determinants of exercise tolerance in HFpEF: role of the heart versus the periphery.Heart failure reviews · 2025Article
- Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart.Cardiovascular research · 2025Review
- Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training.Journal of sport and health science · 2023Review
- Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function.Cardiovascular research · 2021Review
- Superiority of focused ion beam-scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity.Journal of cachexia, sarcopenia and muscle · 2021Article
- Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism.Cell death & disease · 2021Article
- Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure.ESC heart failure · 2021Article
- Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence.ESC heart failure · 2021Review
- Senescence in Post-Mitotic Cells: A Driver of Aging?Antioxidants & redox signaling · 2021Review
- Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.Frontiers in physiology · 2021Article
- Preserved Skeletal Muscle Mitochondrial Function, Redox State, Inflammation and Mass in Obese Mice with Chronic Heart Failure.Nutrients · 2020Article
- Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy.Journal of the American Heart Association · 2020Article
- Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology.Journal of cachexia, sarcopenia and muscle · 2020Article
- Skeletal and Respiratory Muscle Dysfunctions in Pulmonary Arterial Hypertension.Journal of clinical medicine · 2020Review
- Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.Journal of cachexia, sarcopenia and muscle · 2020Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies in heart failure with reduced ejection fraction (HFrEF) suggest that skeletal muscle mitochondrial impairments are associated with exercise intolerance in men. However, the nature of this relationship in female patients remains to be elucidated. This study aimed to determine the relationship between skeletal muscle mitochondrial impairments and exercise intolerance in male and female patients with HFrEF.
methodsMitochondrial respiration, enzyme activity, and gene expression were examined in pectoralis major biopsies from age-matched male (n = 45) and female (n = 11) patients with HFrEF and healthy-matched male (n = 24) and female (n = 11) controls. Mitochondrial variables were compared between sex and related to peak exercise capacity.
resultsCompared with sex-matched controls, complex I mitochondrial oxygen flux was 17% (P = 0.030) and 29% (P = 0.013) lower in male and female patients with HFrEF, respectively, which correlated to exercise capacity (r = 0.71; P > 0.0001). Female HFrEF patients had a 32% (P = 0.023) lower mitochondrial content compared with controls. However, after adjusting for mitochondrial content, male patients demonstrated lower complex I function by 15% (P = 0.030). Expression of key mitochondrial genes regulating organelle dynamics and maintenance (i.e. optic atrophy 1, peroxisome proliferator-activated receptor γ coactivator-1α, NADH:ubiquinone oxidoreductase core subunit S1/S3, and superoxide dismutase 2) were selectively lower in female HFrEF patients.
conclusionsThese data provide novel evidence that HFrEF induces divergent sex-specific mitochondrial phenotypes in skeletal muscle that predispose towards exercise intolerance, impacting mitochondrial 'quantity' in female patients and mitochondrial 'quality' in male patients. Therapeutic strategies to improve exercise tolerance in HFrEF should consider targeting sex-specific mitochondrial abnormalities in skeletal muscle.
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