Evidence map›Paper›PMID 31433737›Full record

ArticleJournal of the American Heart Association2019

Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.

Shakun Karki, Melissa G Farb, Vishva M Sharma, Sukanta Jash, Elaina J Zizza, Donald T Hess, Brian Carmine, Cullen O Carter, Luise I Pernar, Caroline M Apovian and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. The ApoA5-Cidec axis: keeping fibrosis and MASLD at bay.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.Journal of the American Heart Association · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shakun KarkiEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA.
Melissa G FarbEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA.
Vishva M SharmaDepartment of Biomedical Sciences and Diabetes Institute Ohio University Athens OH.
Sukanta JashDepartment of Biomedical Sciences and Diabetes Institute Ohio University Athens OH.
Elaina J ZizzaEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA.
Donald T HessDepartment of General Surgery Boston University School of Medicine Boston MA.
Brian CarmineDepartment of General Surgery Boston University School of Medicine Boston MA.
Cullen O CarterDepartment of General Surgery Boston University School of Medicine Boston MA.
Luise I PernarDepartment of General Surgery Boston University School of Medicine Boston MA.
Caroline M ApovianEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA.
Vishwajeet PuriDepartment of Biomedical Sciences and Diabetes Institute Ohio University Athens OH.
Noyan GokceEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA.
Boston University · USOhio University · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Anti-Angiogenic Mechanisms in Human ObesityR01HL126141 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2015 to 2019
$2.4M
Identifying a novel regulatory pathway of vascular function in obesityR01HL140836 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, PURI, VISHWAJEET · 2018 to 2021
$2.2M
Cide Proteins and Regulation of Energy ExpenditureR01DK101711 · NIDDK · OHIO UNIVERSITY ATHENS · PI PURI, VISHWAJEET · 2014 to 2016
$1.1M
Determinants of obesity-associated insulin resistanceK23HL135394 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, MELISSA G · 2017 to 2021
$895k
FSP27 regulation of vascular function in human obesityK01DK114897 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KARKI, SHAKUN · 2018 to 2021
$608k
NHLBI NIH HHS K23 HL135394NHLBI NIH HHS R01 HL126141NHLBI NIH HHS R01 HL140836NIDDK NIH HHS K01 DK114897NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK101711
6 · The paper itself

Abstract

Background Pathophysiological mechanisms that connect obesity to cardiovascular disease are incompletely understood. FSP27 (Fat-specific protein 27) is a lipid droplet-associated protein that regulates lipolysis and insulin sensitivity in adipocytes. We unexpectedly discovered extensive FSP27 expression in human endothelial cells that is downregulated in association with visceral obesity. We sought to examine the functional role of FSP27 in the control of vascular phenotype. Methods and Results We biopsied paired subcutaneous and visceral fat depots from 61 obese individuals (body mass index 44±8 kg/m

Indexed as

Neovascularization, PhysiologicVasodilationAdiposityAdultApoptosis Regulatory ProteinsCardiovascular DiseasesCells, CulturedEndothelial CellsFemaleHumansIntra-Abdominal FatMaleMicrovesselsMiddle AgedNitric OxideNitric Oxide Synthase Type IIIApoptosis Regulatory ProteinsCIDEC protein, humanNitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesisendothelial dysfunctionendothelial functionobesityvasodilation

Identifiers

PMID31433737
PMCPMC6585348
OpenAlexW2947383751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.