Evidence map›Paper›PMID 31436906›Full record

ArticleJournal of cellular and molecular medicine2019

The phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux.

Chih-Chan Lien, Chia-Hui Chen, Yeng-Ming Lee, Bei-Chia Guo, Li-Ching Cheng, Ching-Chien Pan, Song-Kun Shyue, Tzong-Shyuan Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chih-Chan LienGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Hui ChenDepartment of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yeng-Ming LeeInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Bei-Chia GuoGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Li-Ching ChengDivision of Basic Medical Sciences, Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Ching-Chien PanInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Song-Kun ShyueInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-1057-8696
Tzong-Shyuan LeeGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-9593-4062
Institute of Biomedical Sciences, Academia Sinica · TWNational Taiwan University · TWChang Gung University of Science and Technology · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of soluble epoxide hydrolase (sEH) to atherosclerosis has been well defined. However, less is understood about the role of sEH and its underlying mechanism in the cholesterol metabolism of macrophages. The expression of sEH protein was increased in atherosclerotic aortas of apolipoprotein E-deficient mice, primarily in macrophage foam cells. Oxidized low-density lipoprotein (oxLDL) increased sEH expression in macrophages. Genetic deletion of sEH (sEH

Indexed as

AnimalsApolipoproteins EAtherosclerosisATP Binding Cassette Transporter 1CholesterolEpoxide HydrolasesFoam CellsLipid MetabolismLipoproteins, LDLMacrophagesMiceMice, Inbred C57BLPhosphoprotein PhosphatasesPhosphorylationProtein BindingABCA1 protein, humanApoe protein, mouseApolipoproteins EATP Binding Cassette Transporter 1CholesterolEPHX2 protein, humanEphx2 protein, mouseEpoxide HydrolasesLipoproteins, LDLoxidized low density lipoproteinPhosphoprotein PhosphatasesABCA1macrophage foam cellphosphatasesoluble epoxide hydrolase

Identifiers

PMID31436906
PMCPMC6787517
OpenAlexW2969917637

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.