ArticleDiabetes2019
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence.Clinical obesity · 2026Article
- Monoallelic SH2B1 Variants in Neurodevelopmental Disorders: Phenotypic Expansion and Functional Characterization of Rare Variants.Molecular genetics & genomic medicine · 2026Article
- Nutraceuticals as modulators of genetic, epigenetic and hormonal factors in obesity.European journal of clinical nutrition · 2026Review
- Hypothalamic obesity.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- Identification of βIIΣ1-Spectrin as a Binding Partner of the GH-regulated Human Obesity Scaffold Protein SH2B1.Endocrinology · 2025Article
- Endogenous SH2B1 protein localizes to lamellipodia and filopodia: platinum replica electron-microscopy study.microPublication biology · 2025Article
- Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains.ACS chemical biology · 2024Article
- Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers.Journal of obesity & metabolic syndrome · 2024Article
- SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- 2022 Cannon lecture: an ode to signal transduction: how the growth hormone pathway revealed insight into height, malignancy, and obesity.American journal of physiology. Endocrinology and metabolism · 2023Review
- Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease.Cell reports. Medicine · 2023Article
- The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.The American journal of clinical nutrition · 2023Article
- Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance.Endocrinology · 2023Article
- Review
- The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons.Journal of cell science · 2022Article
- Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study.European journal of nutrition · 2021Article
- Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity.Diabetes · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 2 countries.
Anabel FloresCell and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-1764-4278
Lawrence S ArgetsingerDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Lukas K J StadlerUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Alvaro E MalagaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Paul B VanderDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Lauren C DeSantisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Ray M JoeCell and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI.
Joel M ClineDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Julia M KeoghUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Elana HenningUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Ines BarrosoMRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Edson Mendes de OliveiraUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Gowri ChandrashekarDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Erik S ClutterDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Yixin HuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Jeanne StuckeyLife Sciences Institute and Departments of Biological Chemistry and Biophysics, University of Michigan, Ann Arbor, MI.
I Sadaf FarooqiUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Martin G MyersCell and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI.
Christin Carter-SuCell and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI cartersu@umich.edu.ORCID 0000-0001-5266-1271
University of Michigan · USWellcome/MRC Institute of Metabolic Science · GB
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3MGrowth Hormone Regulation of SH2B1R01DK054222 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARTER-SU, CHRISTIN · 1999 to 2020
$7.7MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MSYTEMS AND INTEGRATIVE BIOLOGYT32GM008322 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 1990 to 2020
$5.7MCellular and Molecular Mechanisms of SH2B1 Mutations That Cause Profound Childhood ObesityR01DK107730 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARTER-SU, CHRISTIN · 2016 to 2020
$2.3MHoward Hughes Medical InstituteMedical Research CouncilNIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK054222NIDDK NIH HHS R01 DK107730NIDDK NIH HHS U2C DK110768NIGMS NIH HHS T32 GM008322Wellcome TrustWellcome Trust 100574/Z/12/ZWellcome Trust 207462/Z/17/ZWellcome Trust WT206194
Abstract
Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with severe obesity, insulin resistance, and neurobehavioral abnormalities in mice and humans. Here, we identify 15
Indexed as
Adaptor Proteins, Signal TransducingAdiposityAdolescentAnimalsChildChild, PreschoolEnergy MetabolismFemaleGlucose IntoleranceHomeostasisHumansInsulin ResistanceMaleMiceMice, TransgenicPediatric ObesityAdaptor Proteins, Signal TransducingSH2B1 protein, human
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.