Evidence map›Paper›PMID 31443274›Full record

ReviewJournal of clinical medicine2019

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits.

Yu-Kai Kuo, I-Chan Lin, Li-Nien Chien, Tzu-Yu Lin, Ying-Ting How, Ko-Hua Chen, Gregory J Dusting, Ching-Li Tseng

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Oral Intake ofBiomedicines · 2025
    Article
  8. Article
  9. Article
  10. Correlation Between Tear Film Stability and Myopia in Children.Clinical ophthalmology (Auckland, N.Z.) · 2025
    Article
  11. Nucleic acid drugs: recent progress and future perspectives.Signal transduction and targeted therapy · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yu-Kai KuoSchool of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
I-Chan LinDepartment of Ophthalmology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Li-Nien ChienSchool of Health Care Administration, College of Management, , Taipei Medical University, Taipei 11031, Taiwan.
Tzu-Yu LinDepartment of Ophthalmology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Ying-Ting HowGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Ko-Hua ChenDepartment of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Gregory J DustingCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia.
Ching-Li TsengGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. chingli@tmu.edu.tw.ORCID 0000-0001-9446-4030
Taipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWTaipei Veterans General Hospital · TWThe University of Melbourne · AU

Funding

Ministry of Science, Taiwan MOST 106-2628-E-038-001-MY3Shuang Ho Hospital, Taipei Medical University 107TMU-SHH-18
6 · The paper itself

Abstract

Dry eye disease (DED) has become common on a global scale in recent years. There is a wide prevalence of DED in different countries based on various ethnicities and environment. DED is a multifactorial ocular disorder. In addition to advanced age and gender, such factors as living at high altitude, smoking, pterygium, prolonged use of consumer electronics or overingesting of caffeine or multivitamins are considered to be the major risk factors of DED. We report the DED epidemiology in Taiwan firstly in this article. According to the pathophysiological factors and changes inthe composition of the tear film in DED, it can be categorized into several subtypes, including lipid anomaly dry eye, aqueous tear deficiency, allergic and toxic dry eye among others. Each subtype has its own cause and disease management; therefore, it is important for ophthalmologists to identify the type through literature review and investigation. The management of DED, relies not only on traditional medications such as artificial tears, gels and ointments, but also newer treatment options such as acupuncture, SYL1001, and nanomedicine therapy. We also conducted a comprehensive literature review including common subtypes and treatment of DED. Clearly, more clinical trials are needed to assess the efficacy and safety of the various treatments and common subtypes of DED.

Indexed as

DED treatmentdry eye disease (DED)nanomedicineprevalencerisk factorsubtype

Identifiers

PMID31443274
PMCPMC6722537
OpenAlexW2967290069

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.