ArticleJournal of neurology2019
Arterial ischemic stroke in infants, children, and adolescents: results of a Germany-wide surveillance study 2015-2017.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Dynamic Changes in Endothelial Glycocalyx and Inflammatory Response in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy: Pathophysiological Aspects and Clinical Implications.Neurology international · 2026Review
- Arterial ischaemic stroke in adolescents and very young adults-results of a European cohort.European stroke journal · 2026Article
- Article
- Pediatric Stroke in a United Arab Emirates (UAE) Tertiary Care Center: A Retrospective Descriptive Study.Cureus · 2025Article
- Paediatric acute liver failure: A prospective, nationwide, population-based surveillance study in Germany.Journal of pediatric gastroenterology and nutrition · 2025Article
- Acute arterial ischemic stroke in children: single-center experience.Arquivos de neuro-psiquiatria · 2025Article
- Comparison of Risk Factors and Outcomes in Pediatric Posterior and Anterior Circulation Arterial Ischemic Stroke: A Cross-Sectional Analysis.Iranian journal of child neurology · 2025Article
- Pediatric intensive care unit admissions network-rationale, framework and method of operation of a nationwide collaborative pediatric intensive care research network in Germany.Frontiers in pediatrics · 2023Article
- Analysis of 622 paediatric hospitalisations due to arterial ischaemic stroke in Poland - National Health Fund registry-based study from 2011 to 2020.Archives of medical science : AMS · 2023Article
- [Arterial ischemic stroke in childhood and adolescence : Time-critical emergency in pediatrics].Der Nervenarzt · 2022Article
- Adverse motor outcome after paediatric ischaemic stroke: A nationwide cohort study.Paediatric and perinatal epidemiology · 2022Article
- Childhood strokes in China describing clinical characteristics, risk factors and performance indicators: a case-series study.Stroke and vascular neurology · 2022Article
- [Stroke alarm-Arterial ischemic stroke as one of the most time-critical emergencies in children and adolescents].Der Nervenarzt · 2022Review
- Intraosseous access in neonates is feasible and safe - An analysis of a prospective nationwide surveillance study in Germany.Frontiers in pediatrics · 2022Article
- Acute ischemic stroke in childhood: a comprehensive review.European journal of pediatrics · 2022Review
- Recanalization strategies in childhood stroke in Germany.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChildhood arterial ischaemic stroke (AIS) is rare, but causes significant morbidity and mortality. We aimed to investigate incidence, age-dependent clinical presentation, and risk factors and to discuss the medical care situation in Germany.
methodsThis prospective epidemiological study was conducted via ESPED (Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland), a hospital-based German nation-wide surveillance unit for rare pediatric diseases. Children aged 28 days-18 years with first AIS between January 2015 and December 2017 were included.
resultsIn the 3-year period, 164 children were reported. Incidence showed peaks in infants, children < 2 years of age, and adolescents (12-18 years), with a significant male predominance observed in adolescents only. Independent of age, most children (91%) presented with focal symptoms, particularly with acute hemiparesis. The occurrence of seizures in infants (57%) and more nonspecific symptoms in school-children and adolescents (54%) is considered noteworthy. Prothrombotic states (34%), cardiac disorders (29%), and arteriopathies (19%) were the most frequently identified risk factors. The majority of children (72/131, thus 55%) were discharged home after acute care phase. At time of discharge, most common neurological symptoms were hemiparesis (42%), facial palsy (15%), and speech disturbance (12%).
conclusionThis study provides population-based data of childhood AIS which may be useful for further research. The improvement of acute stroke management is needed for children, but also the standardization of post-stroke care in the outpatient setting has to be structured. Considering the higher stroke incidence in (male) adolescents, it is advisable to combine research activities in adolescents and young adults.
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